Neuer mRNA-Krebsimpfstoff löst heftige Immunantwort zur Bekämpfung eines bösartigen Hirntumors aus

https://medicalxpress.com/news/2024-05-mrna-cancer-vaccine-triggers-fierce.html

13 comments

  3. now *they* want to take away my tumor too?????????????????????????????

  5. If anything can be said to have been a silver lining to the Pandemic, its that the crash program to develop viable mRNA vaccines for COVID probably did more to advance every other mRNA vaccine than would have otherwise been possible.

  6. Paper link: https://www.cell.com/cell/fulltext/S0092-8674(24)00398-2

    Abstract:Cancer immunotherapy remains limited by poor antigenicity and a regulatory tumor microenvironment (TME). Here, we create “onion-like” multi-lamellar RNA lipid particle aggregates (LPAs) to substantially enhance the payload packaging and immunogenicity of tumor mRNA antigens. Unlike current mRNA vaccine designs that rely on payload packaging into nanoparticle cores for Toll-like receptor engagement in immune cells, systemically administered RNA-LPAs activate RIG-I in stromal cells, eliciting massive cytokine/chemokine response and dendritic cell/lymphocyte trafficking that provokes cancer immunogenicity and mediates rejection of both early- and late-stage murine tumor models. In client-owned canines with terminal gliomas, RNA-LPAs improved survivorship and reprogrammed the TME, which became “hot” within days of a single infusion. In a first-in-human trial, RNA-LPAs elicited rapid cytokine/chemokine release, immune activation/trafficking, tissue-confirmed pseudoprogression, and glioma-specific immune responses in glioblastoma patients. These data support RNA-LPAs as a new technology that simultaneously reprograms the TME while eliciting rapid and enduring cancer immunotherapy.

  7. Something like this would be a major win for mRNA vaccine uptake. If it can greatly slow or even cure cancers like these, it doesn’t really matter what the long term side effects are (common refrain against COVID vaccines). Should help fix the mRNA ‘brand’ among the skeptics.

  8. While there are plenty of people that will say “Durrr, people that didn’t take the covid vax will fear this too”, that might be the case. I imagine that some people might also weigh the dangers of a malignant brain tumor over the dangers of a bad flu (read: covid), and as such would be more willing to get this treatment.

  10. So for these vaccines, are they given prior to any cancer diagnosis, or after?

  12. My young, beautiful, amazing wife and mother of my child died of Glioblastoma at thirty-four years old.

    We tried everything.

    I spent every penny I had to get her every possible option and medical trial possible. We moved around the country. I sold my company and took two years off just doing everything with her we could to give her more time.

    The first year was like a horror movie where you and your partner are trying to escape the monster but you’re running in slow motion and everywhere you turn it just pops up.

    The second year the steroids, surgery, stroke, and experimental medicine had already killed the person she was. She was just a zombie waiting to die.

    She passed when our little girl was three, five years ago.

    While I wish this medicine was available to her obviously, I’m just so glad that a glioblastoma isn’t going to always be a death sentence forever. It’s something noone deserves to go through. Not the victim. Not their family.

    God speed mRNA researchers and scientists.

    This is real, honest to goodness hero stuff you’re doing.

    Respect.

  13. I lost a parent to glioblastoma who was involved in a similar study (they used the tumor to create a vaccine). Here’s hoping they’ve made a breakthrough in this tech and that’s it cures it going forward. It’s a heartbreaking disease.

Leave a Reply