Ireland makes seven changes, while Dan Sheehan takes over as captain for the first time as Caelan Doris is sidelined due to a knee injury.
At eight, Jack Conan replaces Doris, and Sheehan takes Ronan Kelleher’s position at hooker due to injury.
Prop Garry Ringrose is picked over Bundee Aki, Mack Hansen recovers from injury, Jamie Osborne receives his first Six Nations cap at the age of 15, and Thomas Clarkson gets his first Test start.
Following his injury, James Ryan, Finlay Bealham, and Bundee Aki were benched, and Joe McCarthy was also called up.
Uncapped Leinster prop For the first time, Jack Boyle is part of a matchday squad.
One of eight changes is Gareth Anscombe, who teams up with Tomos Williams for just the second time in this competition and earns his first Six Nations start since 2019.
Josh Adams, who played in the English Championship the previous season, is replaced by Ellis Mee, who makes his debut on the flank.
WillGriff John, who is 32 years old, is getting his first cap in three years. In a revamped front row, Nicky Smith and Elliot Dee join him, and Dafydd Jenkins makes a comeback after missing Rome because of sickness.
Tommy Reffell also gets called up, while Max Llewellyn makes his Six Nations debut.
Wales’s match against Grand Slam-chasing Ireland in Cardiff in round three of the Men’s Six Nations marks the beginning of life following Warren Gatland’s attempt to halt their worrying decline into rugby’s darkest abysses.
Following Wales’ record-breaking 14th consecutive Test defeat to Italy in round two, Gatland resigned as head coach.
Cardiff head coach Matt Sherratt has temporarily taken his place. His first assignment is to play an Irish squad that is trying to become the first team in the 142-year history of this event to win three straight outright titles in front of a sold-out Principality Stadium.
The visitors are the clear favourites to win the 14th Triple Crown after dominating their first two games against England and Scotland.
Stick around for all the latest updates at sold-out Principality Stadium. Kick off is at 2.15pm GMT.
Credit: Inpho