13th March 2025 – (Luxembourg City) Prince Frederik of Luxembourg, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, has passed away at the age of 22 following an eight-year struggle with POLG mitochondrial disease. His death was announced by his father on 7th March in a heartfelt message.
Frederik, who was diagnosed with the rare condition at 14, sought to raise awareness for the disease through the establishment of the POLG Foundation. The genetic disorder, which disrupts cellular energy production, leads to progressive organ dysfunction and currently has no cure. Symptoms, including liver failure, muscle weakness, and epilepsy, are often difficult to detect in early stages.
In a tribute to his son, Prince Robert described Frederik’s resilience and grace in the face of his illness. “Though he always made it very clear that he did not want this dreadful disease to define him, Frederik immediately identified with and helped shape the mission of The POLG Foundation,” Robert said.
Director Mei Fa Tan, who worked with the young royal on the foundation’s short film, recalled Frederik’s passion for film, music, and conversation, despite the limitations imposed by his illness. “It was painful to watch him try his best when his body wouldn’t allow him to do as much,” she shared.
Frederik also appeared in the foundation’s inaugural production, reflecting on his journey in a poignant voiceover. “When you’re a kid, you’ve got all these dreams, all these aspirations… Slowly, the world gets smaller and smaller,” he said.
Frederik’s passing, just a day after International Rare Disease Day, underscores the challenges faced by the estimated 300 million people living with rare conditions worldwide. His legacy, marked by his advocacy and commitment to medical research, continues through the work of the POLG Foundation.