(Bloomberg) — Shares of pharmaceutical companies fell across Europe and Asia after President Donald Trump said he planned to order a cut in US prescription drug costs to bring them in line with other countries.

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In Europe, obesity-drug maker Novo Nordisk A/S fell as much as 8.6% at the open, one of the steepest decliners in the Stoxx 600 Health Care Index, which slid 3.3%.

Drugmakers were the worst-performing sector in Japan on Monday, dragging the benchmark Topix lower despite hopes of a US-China trade deal broadly boosting markets across Asia. Chugai Pharmaceutical Co. plunged as much as 10%, the most since February 2024, with peers Daiichi Sankyo Co. sliding 7.8% to the day’s low and Takeda Pharmaceutical Co. losing over 5%.

Meanwhile in Hong Kong, BeiGene Ltd. tumbled as much 8.8% and Innovent Biologics Inc. dropped 6.4%. In South Korea, SK Biopharmaceuticals Co., Celltrion Inc. and Samsung Biologics Co. all fell over 3%. India’s Sun Pharmaceutical Industries Ltd. lost 7% at one point, with Lupin Ltd. and Aurobindo Pharma Ltd. falling around 3%

The declines come after Trump said on social media he intends to sign an executive order lowering the price of prescription medicines at 9 a.m. on Monday in Washington, after reports emerged of the plan last week. The announcement is pressuring drug-related stocks, on worries their profits will take a hit if they have to reduce prices in the US.

“This has the potential to be very negative for the industry,” Bank Vontobel analyst Stefan Schneider said in a note, adding that the plan will probably be directed at Medicare, Medicaid and some hospitals. “Such a move will likely face lawsuits by the industry,” Schneider said.

READ: Trump Seeks to Align US Drug Costs With Cheapest Ones Abroad

Although the feasibility of Trump’s plan is “questionable,” his announcement is negative for the pharmaceutical sector, Hidemaru Yamaguchi, a health-care sector analyst at Citigroup Global Markets Japan Inc., wrote in a note.

Firms that depend on the US for a large chunk of sales, including Japan’s Takeda, Astellas Pharma Inc. and Otsuka Holdings Co., are especially vulnerable, he added. Shares of Astellas and Otsuka also lost over 4% Monday.

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