Mr Vance, 40, and his family have chosen to spend their summer holiday in the UK, reports in The Telegraph this weekend claimed.
The 50th US Vice President, who hails from Middletown, Ohio, is married to lawyer wife Usha, and the couple have three young children.
Mr Vance and his family’s visit is expected to take place in August shortly after Donald Trump visits the UK – with the US President due to meet Prime Minister Sir Keir Starmer.
The Telegraph cited sources familiar with the family’s itinerary and added that they are looking to rent a Cotswolds cottage.
As many as three separate sources explained the plans to The Telegraph, though one said that the plans are yet to be finalised.
A Whitehall source has told the paper: “Whatever any policy differences, the history, heritage and appeal of the UK are a huge draw to the current administration.”
The Stop Trump Coalition, consisting of anti-Trump demonstrators, trade unions and pro-Palestine protesters, has said: “We are meeting Trump with protests in Aberdeen and Edinburgh this month, and then in London and Windsor in September.
“JD Vance is every bit as unwelcome in the UK as Donald Trump.
“We remember how Vance cut short his ski trip in Vermont because he was so enraged by the sight of a few protesters.
“We are sure that, even in the Cotswolds, he will find the resistance waiting.”
Mr Vance’s reported Cotswold plans come as a famous householder in the region from the US, Ellen DeGeneres, confirmed that she moved to the UK because of Donald Trump.
At an event at Cheltenham’s Everyman Theatre with presenter Richard Bacon on Sunday, July 20, the comedian and talk show host said that her and her wife, Portia de Rossi, had originally planned to spend three or four months in the UK each year and bought what they believed would be ‘a part-time house’.
“We got here the day before the election and woke up to lots of texts from our friends with crying emojis, and I was like: ‘He got in,'” Ms DeGeneres, 67, said.
“And we’re like: ‘We’re staying here.'”