Vance will stay at Carnell Estates, a privately owned estate which has a 14th century tower and 10-bedroom mansion situated on over 2,000 acres of land.
The estate is about a 40-minute drive away from Trump’s Turnberry golf club.
Police Scotland previously confirmed they had plans in place for “a significant policing operation.”
Officers were seen at the estate ahead of Vance’s arrival on Wednesday and some road closures were in place.
He was greeted at the resort by dozens of pro-Palestinian protesters.
The demonstrators were kettled by police as they bashed pots and pans, waved Palestinian flags and shouted chants.
Police had initially told the protesters they would need to move and that officers move them on if they refused to leave to a different space nearby.
Airspace restrictions are in place around the estate until Sunday.
Mr Vance will reportedly spend five days in Scotland – the same amount of time his boss did during his trip to the country last month.