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Prince William didn’t wait for the death of dad King Charles to reveal that “change” will be on his “agenda” when he ascends to the throne — and insiders predict the ruthless heir’s royal flush will exile his enemies and banish embarrassing family members.

The Prince of Wales, 43, made his candid confession during a discussion with Eugene Levy in Windsor, England, for the Canadian actor’s Apple TV+ show The Reluctant Traveler.

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In the interview, the future monarch says it’s “safe to say” that he’ll do things differently than his predecessors, adding that he doesn’t “fear” change and that he believes the undisclosed alterations are things that he thinks “need to happen.”

Now, sources reveal William’s pronouncement has sparked speculation about which of his relatives could be on the chopping block.

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As the National Enquirer has reported, 76-year-old Charles is battling an undisclosed form of cancer that is said to be incurable, and those close to him fear the disease may cut short his reign, which began in September 2022 with death of his mother, Queen Elizabeth.

Prince Harry, William’s brother, recently shared a 55-minute private tea with their father during a visit to the U.K. from his home in California, which some say is evidence that the sentimental king may be willing to welcome his second-born back into the royal fold to represent the crown.

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As Enquirer readers know, Harry, 41, and his Suits star wife, Meghan, 44, ditched palace duties in 2020 to chase lucrative Hollywood deals. But since settling in Montecito, Calif., where they’re raising kids Prince Archie, 6, and Princess Lilibet, 4, the Duke and Duchess of Sussex have given several interviews bashing the royal family.

And insiders say the Sussexes may have sunk their own ship with their loose lips.

Royal expert Hilary A. Fordwich notes, “King Charles might try to let Harry and Meghan do more, but I can tell you Prince William has no tolerance for that. He does not trust his brother. He basically does not want to address it. He doesn’t want to have anything else to do with him.”

Fordwich also believes that William’s uncle Prince Andrew — as well as the Duke of York’s ex-wife, Sarah Ferguson — may be on the outs due to their shameful past friendship with dead pedophile Jeffrey Epstein.

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The expert explains, “William is laser-focused on the endurance of the monarchy. He has been hurt more greatly than his father by many of the actions his uncle and Prince Harry have taken. And he is more concerned and sees them as a liability more than his father ever did. So, I think they are going to have a tougher time when he does become king.”

Fordwich expects Andrew — whose damningly supportive email to Epstein was recently released — and Fergie, who once called the financier a “supreme friend,” will be “out of sight” once William wears the crown.

Fergie’s rep has claimed that her gushing remarks in a 2011 email to Epstein after she’d publicly vowed to cut ties with the monstrous moneyman were intended to dissuade him from following through on his threat to ruin the York family.

Meanwhile, Andrew has denied the claims of Epstein’s late alleged sex slave Virginia Guiffre, who accused the duke of sexually assaulting her when she was 17 — but he gave her an estimated $16 million in 2022 to settle her civil lawsuit against him.

Fordwich says when Andrew is “prominent,” he’s “bringing attention to scandals,” and “Prince William has no tolerance for scandals that tarnish the monarchy.”

And regarding Fergie, Fordwich says, “She is now persona non grata. She has undermined herself, and I don’t see any more public role for her ever again.”

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Fordwich believes Queen Camilla, the king’s wife and former mistress, can maintain an “amicable” relationship with her oldest stepson if she remains devoted to her charity work and does not overstep her bounds.

A courtier says, “People expect William to be iron-fisted in his mission to protect the monarchy — and preserve it for his 12-year-old son and heir, Prince George.”