Grana R, Benowitz N, Glantz SA. E-cigarettes: a scientific review. Circulation. 2014;129:1972–86. https://doi.org/10.1161/CIRCULATIONAHA.114.007667.
Harvanko AM, Havel CM, Jacob P, Benowitz NL. Characterization of nicotine salts in 23 electronic cigarette refill liquids. Nicotine Tob Res. 2020;22:1239–43. https://doi.org/10.1093/ntr/ntz232.
Sassano MF, Davis ES, Keating JE, Zorn BT, Kochar TK, Wolfgang MC, et al. Evaluation of e-liquid toxicity using an open-source high-throughput screening assay. PLoS Biol. 2018;16:e2003904. https://doi.org/10.1371/journal.pbio.2003904.
CDC. Health Effects of Vaping. Smoking and Tobacco Use. 2025. https://www.cdc.gov/tobacco/e-cigarettes/health-effects.html. Accessed 27 Jun 2025.
Commissioner O of the E-cigarette: safety communication – related to seizures reported following E-cigarette Use, particularly in youth and young adults. FDA. 2024.
Krishnasamy VP, Hallowell BD, Ko JY, Board A, Hartnett KP, Salvatore PP, et al. Update: characteristics of a nationwide outbreak of E-cigarette, or vaping, product use-associated lung injury – United States, August 2019-January 2020. MMWR Morb Mortal Wkly Rep. 2020;69:90–4. https://doi.org/10.15585/mmwr.mm6903e2.
Milkowski M, Olesk J, Asfura DM, Barco C, Cervera C, Wachira M, et al. Youth vaping in the digital age: a systematic review of technological interventions for prevention and cessation. In: The 2025 ACM International Conference on Supporting Group Work. Hilton Head South Carolina USA: ACM; 2025. p. 58–67. https://doi.org/10.1145/3688828.3699642.
WHO report on the global tobacco epidemic, 2023: protect people from tobacco smoke. https://www.who.int/publications/i/item/9789240077164. Accessed 27 Jun 2025.
The Global State of Tobacco Harm Reduction 2024: A Situation Report. Global State of Tobacco Harm Reduction. https://gsthr.org/resources/thr-reports/the-global-state-of-tobacco-harm-reduction-2024-a-situation-report/. Accessed 27 Jun 2025.
Burning Issues: The Global State of Tobacco Harm Reduction 2020. Global State of Tobacco Harm Reduction. https://gsthr.org/resources/thr-reports/burning-issues-global-state-tobacco-harm-reduction-2020/. Accessed 27 Jun 2025.
Camenga DR, Klein JD. Tobacco use disorders. Child Adolesc Psychiatr Clin N Am. 2016;25:445–60. https://doi.org/10.1016/j.chc.2016.02.003.
Martins BNFL, Normando AGC, Rodrigues-Fernandes CI, Wagner VP, Kowalski LP, Marques SS, et al. Global frequency and epidemiological profile of electronic cigarette users: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2022;134:548–61. https://doi.org/10.1016/j.oooo.2022.07.019.
Stoumpos AI, Kitsios F, Talias MA. Digital transformation in healthcare: technology acceptance and its applications. Int J Environ Res Public Health. 2023;20:3407. https://doi.org/10.3390/ijerph20043407.
Wienert J, Jahnel T, Maaß L. What are digital public health interventions? First steps toward a definition and an intervention classification framework. J Med Internet Res. 2022;24:e31921. https://doi.org/10.2196/31921.
Vasanthan L, Natarajan SK, Babu A, Kamath MS, Kamalakannan S. Digital health interventions for improving access to primary care in India: a scoping review. PLoS Glob Public Health. 2024;4:e0002645. https://doi.org/10.1371/journal.pgph.0002645.
UCR Health and UCR School of Medicine, Riverside, CA, USA, Linwood SL, editors. Digital Health. Exon Publications; 2022. https://doi.org/10.36255/exon-publications-digital-health.
Kelpin S, Brockman TA, Decker PA, Young A, Boehmer K, Nguyen A, et al. Increasing digital equity to promote online smoking cessation program engagement among rural adults: a randomized controlled pilot trial. Commun Med. 2024;4:194. https://doi.org/10.1038/s43856-024-00624-6.
Liu L, Zhao Y, Li J, Zhang N, Lan Z, Liu X. Efficacy of digital therapeutics in smoking cessation: a systematic review and meta-analysis. Medicine in Novel Technology and Devices. 2023;17:100209. https://doi.org/10.1016/j.medntd.2023.100209.
Zhou X, Wei X, Cheng A, Liu Z, Su Z, Li J, et al. Mobile Phone-Based Interventions for Smoking Cessation Among Young People: Systematic Review and Meta-Analysis. JMIR Mhealth Uhealth. 2023;11:e48253. https://doi.org/10.2196/48253.
Yao R, Zhang W, Evans R, Cao G, Rui T, Shen L. Inequities in health care services caused by the adoption of digital health technologies: scoping review. J Med Internet Res. 2022;24:e34144. https://doi.org/10.2196/34144.
Badr J, Motulsky A, Denis J-L. Digital health technologies and inequalities: a scoping review of potential impacts and policy recommendations. Health Policy. 2024;146:105122. https://doi.org/10.1016/j.healthpol.2024.105122.
Ghorai K, Akter S, Khatun F, Ray P. Mhealth for smoking cessation programs: a systematic review. JPM. 2014;4(3):412–23. https://doi.org/10.3390/jpm4030412.
Prutzman YM, Wiseman KP, Grady MA, Budenz A, Grenen EG, Vercammen LK, et al. Using digital technologies to reach tobacco users who want to quit: evidence from the National Cancer Institute’s Smokefree.gov Initiative. Am J of Preventive Med. 2021;60:S172-84. https://doi.org/10.1016/j.amepre.2020.08.008.
Lachance A, Da SMAR, Yameogo A, Plaisimond J, Naye F, Yousefi F, et al. Interactive conversational agents for cigarette-smoking and vaping cessation: a mixed-methods systematic review. MTI. 2024;8:101. https://doi.org/10.3390/mti8110101.
V D, Jodalli PS, B R A. The role of chatbots and virtual assistants in enhancing tobacco cessation counselling. Front Digit Health. 2025;7:1503227. https://doi.org/10.3389/fdgth.2025.1503227.
Gopal B. Tobacco addiction: Revolutionising quitting with innovation. Policy Circle. 2023. https://www.policycircle.org/opinion/tobacco-addiction-world-lung-day/.
Bendotti H, Ireland D, Lawler S, BBiomedSc DO, Gartner C, Marshall HM. Introducing quin: the design and development of a prototype chatbot to support smoking cessation. Nicotine Tob Res. 2024;26:612–20. https://doi.org/10.1093/ntr/ntad217.
Liu L, Zhao Y, Li J, Zhang N, Lan Z, Liu X. Efficacy of digital therapeutics in smoking cessation: a systematic review and meta-analysis. Medicine in Novel Technology and Devices. 2023. https://doi.org/10.1016/j.medntd.2023.100209.
Chidambaram S, Jain B, Jain U, Mwavu R, Baru R, Thomas B, et al. An introduction to digital determinants of health. PLoS Digit Health. 2024;3:e0000346. https://doi.org/10.1371/journal.pdig.0000346.
Kickbusch I, Piselli D, Agrawal A, Balicer R, Banner O, Adelhardt M, et al. The lancet and financial times commission on governing health futures 2030: growing up in a digital world. Lancet. 2021;398:1727–76. https://doi.org/10.1016/S0140-6736(21)01824-9.
Global strategy on digital health 2020–2025. https://www.who.int/publications/i/item/9789240020924. Accessed 27 Jun 2025.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https://doi.org/10.1136/bmj.n71.
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Syst Rev. 2016;5:210. https://doi.org/10.1186/s13643-016-0384-4.
Belbasis L, Bellou V, Ioannidis JPA. Conducting umbrella reviews. BMJ Med. 2022;1:e000071. https://doi.org/10.1136/bmjmed-2021-000071.
Palmer AM, Tomko RL, Squeglia LM, Gray KM, Carpenter MJ, Smith TT, et al. A pilot feasibility study of a behavioral intervention for nicotine vaping cessation among young adults delivered via telehealth. Drug Alcohol Depend. 2022;232:109311. https://doi.org/10.1016/j.drugalcdep.2022.109311.
Krishnan N, Berg CJ, Le D, Ahluwalia J, Graham AL, Abroms LC. A pilot randomized controlled trial of automated and counselor-delivered text messages for e-cigarette cessation. Tob Prev Cessat. 2023;9:04. https://doi.org/10.18332/tpc/157598.
Prokhorov AV, Calabro KS, Arya A, Russell S, Czerniak KW, Botello GC, et al. Mobile text messaging for tobacco risk communication among young adult community college students: randomized trial of project debunk. JMIR Mhealth Uhealth. 2021;9:e25618. https://doi.org/10.2196/25618.
Graham AL, Amato MS, Cha S, Jacobs MA, Bottcher MM, Papandonatos GD. Effectiveness of a vaping cessation text message program among young adult e-cigarette users: a randomized clinical trial. JAMA Intern Med. 2021;181:923–30. https://doi.org/10.1001/jamainternmed.2021.1793.
Villanti AC, Peasley-Miklus C, Cha S, Schulz J, Klemperer EM, LePine SE, et al. Tailored text message and web intervention for smoking cessation in U.S. socioeconomically-disadvantaged young adults: a randomized controlled trial. Prev Med. 2022;165:107209. https://doi.org/10.1016/j.ypmed.2022.107209.
Klein EG, Shoben AB, Carpenter KM, Mullis K, Nemeth JM, Mayers E, et al. A randomized clinical trial of a quitline vaping cessation intervention: baseline characteristics of young adult exclusive e-cigarette users seeking treatment. Int J Environ Res Public Health. 2024;21:809. https://doi.org/10.3390/ijerph21060809.
Pallejà-Millán M, Rey-Reñones C, Barrera Uriarte ML, Granado-Font E, Basora J, Flores-Mateo G, et al. Evaluation of the Tobbstop mobile app for smoking cessation: cluster randomized controlled clinical trial. JMIR Mhealth Uhealth. 2020;8:e15951. https://doi.org/10.2196/15951.
Graham AL, Cha S, Jacobs MA, Amato MS, Funsten AL, Edwards G, et al. A vaping cessation text message program for adolescent e-cigarette users: a randomized clinical trial. JAMA. 2024;332:713–21. https://doi.org/10.1001/jama.2024.11057.
Cartujano-Barrera F, Hernández-Torrez R, Cai X, Orfin RH, Azogini C, Chávez-Iñiguez A, et al. Evaluating the immediate impact of graphic messages for vaping prevention among Black and Latino adolescents: a randomized controlled trial. Int J Environ Res Public Health. 2022;19:10026. https://doi.org/10.3390/ijerph191610026.
Elling JM, Crutzen R, Talhout R, de Vries H. Effects of providing tailored information about e-cigarettes in a digital smoking cessation intervention: randomized controlled trial. Health Educ Res. 2023;38:150–62. https://doi.org/10.1093/her/cyad004.
Vickerman KA, Carpenter KM, Mullis K, Shoben AB, Nemeth J, Mayers E, et al. Quitline-based young adult vaping cessation: a randomized clinical trial examining NRT and mHealth. Am J Prev Med. 2025;68:366–76. https://doi.org/10.1016/j.amepre.2024.10.019.
Grouin J-M, Coste M, Lewis J. Subgroup analyses in randomized clinical trials: statistical and regulatory issues. J Biopharm Stat. 2005;15:869–82. https://doi.org/10.1081/BIP-200067988.
Ioannidis JPA. Interpretation of tests of heterogeneity and bias in meta-analysis. J Eval Clin Pract. 2008;14:951–7. https://doi.org/10.1111/j.1365-2753.2008.00986.x.
Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page M, et al. Cochrane Handbook for Systematic Reviews of Interventions version 6.5 (updated August 2024). Cochrane; 2024.
Tran DD, Davis JP, Ring C, Buch K, Fitzke RE, Pedersen ER. Informing the development of interventions for e-cigarette use and prevention of transition to cigarette smoking in young adults: a qualitative study. Prev Med Rep. 2023;35:102332. https://doi.org/10.1016/j.pmedr.2023.102332.
Heshmati J, Pandey A, Benjamen J, Furqan M, Salman M, Visintini S, et al. Vaping cessation interventions: a systematic review and meta-analysis. Tob Control. 2025:tc-2024–058798. https://doi.org/10.1136/tc-2024-058798.
Murray-Smith R, Taylor D. Policy, Regulations, and Risk Assessment. In: Health Care and Environmental Contamination. Elsevier; 2018. p. 239–60. https://doi.org/10.1016/B978-0-444-63857-1.00013-9.
Díaz SAH, Pérez JME. Use of small incentives for increasing participation and reducing dropout in a family drug-use prevention program in a Spanish sample. Subst Use Misuse. 2009;44:1990–2000. https://doi.org/10.3109/10826080902844870.
Quetsch LB, Girard EI, McNeil CB. The impact of incentives on treatment adherence and attrition: a randomized controlled trial of Parent-Child Interaction Therapy with a primarily Latinx, low-income population. Child Youth Serv Rev. 2020;112:104886. https://doi.org/10.1016/j.childyouth.2020.104886.
Dunn A, Alvarez J, Arbon A, Bremner S, Elsby-Pearson C, Emsley R, et al. Investigating the effect of providing monetary incentives to participants on completion rates of referred co-respondents: an embedded randomized controlled trial. Contemp Clin Trials Commun. 2024;38:101267. https://doi.org/10.1016/j.conctc.2024.101267.
Chaffee BW, Gansky SA, Halpern-Felsher B, Couch ET, Essex G, Walsh MM. Conditional risk assessment of adolescents’ electronic cigarette perceptions. Am J Health Behav. 2015;39:421–32. https://doi.org/10.5993/AJHB.39.3.14.
Wallace LN, Roche MJ. Vaping in context: links among e-cigarette use, social status, and peer influence for college students. J Drug Educ. 2018;48:36–53. https://doi.org/10.1177/0047237918807706.
Yoong SL, Stockings E, Chai LK, Tzelepis F, Wiggers J, Oldmeadow C, et al. Prevalence of electronic nicotine delivery systems (ENDS) use among youth globally: a systematic review and meta-analysis of country level data. Aust N Z J Public Health. 2018;42:303–8. https://doi.org/10.1111/1753-6405.12777.
Jaswal N, Bhatt G, Goel S. Awareness of electronic cigarettes in India: findings from the 2016–2017 global adult tobacco survey (GATS). Tob Prev Cessat. 2023;9:03. https://doi.org/10.18332/tpc/156446.
Sumayyia MD, Al-Madaney MM, Almousawi FH. Health information on social media Perceptions, attitudes, and practices of patients and their companions. Saudi Med J. 2019;40:1294–8. https://doi.org/10.15537/smj.2019.12.24682
Graham AL, Cha S, Papandonatos GD, Amato MS, Jacobs MA, Abroms LC, et al. E-cigarette and combusted tobacco abstinence among young adults: secondary analyses from a U.S.-based randomized controlled trial of vaping cessation. Prev Med. 2022;165:107119. https://doi.org/10.1016/j.ypmed.2022.107119.
Butler AR, Lindson N, Livingstone-Banks J, Notley C, Turner T, Rigotti NA, et al. Interventions for quitting vaping. Cochrane Database Syst Rev. 2025;(1):CD016058. https://doi.org/10.1002/14651858.CD016058.pub2.
Bullen C, Howe C, Laugesen M, McRobbie H, Parag V, Williman J, et al. Electronic cigarettes for smoking cessation: a randomised controlled trial. Lancet. 2013;382:1629–37. https://doi.org/10.1016/S0140-6736(13)61842-5.
Hall AK, Cole-Lewis H, Bernhardt JM. Mobile text messaging for health: a systematic review of reviews. Annu Rev Public Health. 2015;36:393–415. https://doi.org/10.1146/annurev-publhealth-031914-122855.
Gentili A, Failla G, Melnyk A, Puleo V, Tanna GLD, Ricciardi W, et al. The cost-effectiveness of digital health interventions: a systematic review of the literature. Front Public Health. 2022;10:787135. https://doi.org/10.3389/fpubh.2022.787135.
Hewitt S, Sephton R, Yeowell G. The effectiveness of digital health interventions in the management of musculoskeletal conditions: systematic literature review. J Med Internet Res. 2020;22:e15617. https://doi.org/10.2196/15617.
Causio FA, Fakhfakh M, Kaur J, Sert B, Gandolfi S, Di Pumpo M, et al. Digital health interventions’ impact on health literacy: a systematic review. Eur J Public Health. 2024;34(Suppl 3):ckae144.1201. https://doi.org/10.1093/eurpub/ckae144.1201.
Dahlgren G, Whitehead M. The dahlgren-Whitehead model of health determinants: 30 years on and still chasing rainbows. Public Health. 2021;199:20–4. https://doi.org/10.1016/j.puhe.2021.08.009.
Chadi N, Hadland SE, Harris SK. Understanding the Implications of the “Vaping Epidemic” among Adolescents and Young Adults: A Call for Action. Subst Abuse. 2019;40:7–10. https://doi.org/10.1080/08897077.2019.1580241.
Chakma JK, Dhaliwal RS, Mehrotra R. White paper on electronic nicotine delivery system. Indian J Med Res. 2019;149:574–83. https://doi.org/10.4103/ijmr.IJMR_957_19.
