Cuomo's Paradox is basically that a factor is both good and bad for health, depending upon disease status. This image shows a beautified version of data from two studies. The left graph shows that higher LDL increases risk of heart disease (O'Keefe et al 2005 in JACC). The right graph shows that higher LDL decreases survival among patients with heart disease (Cho et al 2022 in JAHA).
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