WASHINGTON—Anthropic is racing to resolve its latest conflict with the Trump administration, meeting with officials and dispatching top technical staff to Washington over the weekend in pursuit of a deal to end export restrictions on its most powerful artificial-intelligence models.

The Trump administration on Friday banned foreign governments, companies and individuals from using Anthropic’s Fable 5 and Mythos 5 models, which prompted Anthropic to shut off access to everyone in order to comply. Anthropic said at the time that many foreign governments, companies and individuals, including some foreign-born Anthropic employees, fell under the restriction.

Administration officials and Anthropic leaders spent several hours on calls Saturday discussing Fable 5, a slimmed-down version of Anthropic’s powerful Mythos model meant for the general public, people familiar with the discussions said. The discussions included Commerce Secretary Howard Lutnick and National Cyber Director Sean Cairncross as well as Tom Brown, an Anthropic co-founder who is the company’s chief compute officer, and Sarah Heck, the company’s head of public policy, they said.

On Sunday a group of cybersecurity notables signed a letter calling for the administration to lift the export controls. “This action has taken the best models away from defenders, created market uncertainty, and risked America’s AI leadership without any real risk to justify it,” the letter said.

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