{"id":112282,"date":"2026-08-27T14:42:08","date_gmt":"2026-08-27T14:42:08","guid":{"rendered":"https:\/\/www.europesays.com\/britain\/112282\/"},"modified":"2026-08-27T14:42:08","modified_gmt":"2026-08-27T14:42:08","slug":"astrazeneca-asthma-drug-succeeds-in-oesophagus-trial","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/britain\/112282\/","title":{"rendered":"AstraZeneca asthma drug succeeds in oesophagus trial"},"content":{"rendered":"<p>AstraZeneca\u00a0has announced the success of its asthma drug\u00a0in a\u00a0late-stage oesophagus disease trial.\u00a0\u00a0<\/p>\n<p>The\u00a0British Swedish\u00a0pharmaceutical company\u00a0said on Thursday that Tezspire (tezepelumab-ekko) met the main goals of the trial for treating patients with chronic inflammatory disorder of the oesophagus.\u00a0<\/p>\n<p>Reduction in inflammation<\/p>\n<p>Tezepelumab-ekko,\u00a0\u2060developed with Amgen, was found to significantly reduce inflammation in the oesophagus as well as ease difficulty in swallowing in patients with eosinophilic oesophagitis compared to a placebo at 52 weeks. \u00a0<\/p>\n<p>The\u00a0chronic, immune-mediated inflammatory condition causes painful injury to the throat and oesophagus and is estimated to effect\u00a0than 470,000 people in\u00a0\u200bthe <a href=\"https:\/\/www.emjreviews.com\/emj-gold\/news\/gsk-wins-approval-for-new-hepatitis-b-drug-hibsago\/\" target=\"_blank\" rel=\"noopener nofollow\">United States<\/a>\u00a0alone.\u00a0<\/p>\n<p>This new drug is a monoclonal antibody that works by blocking an\u00a0inflammation-triggering protein known as TSLP\u00a0in the\u00a0early inflammation campaign, helping to ward off\u00a0in conditions\u00a0\u200bdriven by eosinophils\u00a0as well as severe asthma.\u00a0<\/p>\n<p>Already approved in\u00a0a number of\u00a0countries as an add-on treatment for severe asthma,\u00a0tezepelumab-ekko\u00a0has an advantage over other drugs due to its\u00a0four-week\u00a0dosing interval and effectiveness in\u00a0treating epithelial-driven inflammatory diseases, according to\u00a0AstraZeneca.\u00a0<\/p>\n<p>It generated $1.13bn in sales for AstraZeneca in 2025.\u00a0<\/p>\n<p>Focus after failure<\/p>\n<p>Despite the\u00a0promising\u00a0outcome of the trial, investors\u00a0remain\u00a0focussed on the upcoming results of two cancer trials which are seen as\u00a0more supportive\u00a0of the company\u2019s growth prospects and set target to reach\u00a0$80bn in sales by 2030.\u00a0\u00a0<\/p>\n<p>The positive news\u00a0also\u00a0comes after a series of setbacks for the Cambridge-based company that saw both cancer drug\u00a0Wainua\u00a0(eplontersen), and\u00a0Ultomiris\u00a0(ravulizumab-cwvz)\u00a0for rare blood and autoimmune diseases, unexpectedly fail late-stage trials.\u00a0\u00a0<\/p>\n<p>In May, a US regulatory panel rejected its breast cancer drug\u00a0camizestrant\u00a0on the grounds that it had concerns over the trial design, which prompted a 2.5% drop in share price.\u00a0<\/p>\n<p>AstraZeneca\u00a0also made the decision to halt a late-stage trial of\u00a0volrustomig, an experimental lung cancer drug, this month after a committee overseeing the trial concluded it was unlikely to meet its primary goals.\u00a0<\/p>\n<p>As of the most\u00a0recent news, shares remained down\u00a0by\u00a00.6% on Thursday\u00a0morning, having fallen 14% since\u00a0Wainua\u2019s\u00a0trial failure.\u00a0<\/p>\n<p>Featured image:\u00a0Roland Magnusson on\u00a0AdobeStock\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"AstraZeneca\u00a0has announced the success of its asthma drug\u00a0in a\u00a0late-stage oesophagus disease trial.\u00a0\u00a0 The\u00a0British Swedish\u00a0pharmaceutical company\u00a0said on Thursday that&hellip;\n","protected":false},"author":2,"featured_media":112283,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_share_on_mastodon":"0"},"categories":[20662],"tags":[11153],"class_list":["post-112282","post","type-post","status-publish","format-standard","has-post-thumbnail","category-astrazeneca","tag-astrazeneca"],"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@UnitedKingdom\/117168002938465722","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/britain\/wp-json\/wp\/v2\/posts\/112282","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/britain\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/britain\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/britain\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/britain\/wp-json\/wp\/v2\/comments?post=112282"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/britain\/wp-json\/wp\/v2\/posts\/112282\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/britain\/wp-json\/wp\/v2\/media\/112283"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/britain\/wp-json\/wp\/v2\/media?parent=112282"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/britain\/wp-json\/wp\/v2\/categories?post=112282"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/britain\/wp-json\/wp\/v2\/tags?post=112282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}