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The oligonucleotides market offers opportunities in therapeutic applications, particularly for untreated diseases using ASOs, siRNA, and aptamers, with leaders like Alnylam driving innovation. Growth also spans diagnostics and research, supported by evolving ESG trends and regional market expansion.
Oligonucleotides Market
Oligonucleotides Market · GlobeNewswire Inc.
Dublin, March 02, 2026 (GLOBE NEWSWIRE) — The “Oligonucleotides: Global Markets” report has been added to ResearchAndMarkets.com’s offering.
The global market for oligonucleotides was valued at $9.1 billion in 2025 and is estimated to reach $15.7 billion by 2030, at a compound annual growth rate (CAGR) of 11.5% from 2025 through 2030.
The use of oligonucleotides as therapeutic and diagnostic agents is an emerging field of study. Antisense oligonucleotides (ASOs), small interfering RNA (siRNA), microRNA (miRNA), aptamers and DNAzymes are used in the treatment of various diseases. Oligonucleotide therapeutics represent a potential new modality for treating diseases.
Many potential disease targets for oligonucleotide-based therapies currently lack effective or appealing treatment options. Alnylam Pharmaceuticals Inc. is a leading company in the market, with many approved products in strategic therapeutic areas, including genetic medicine, cardio-metabolic disease, infectious disease and central nervous system (CNS) and ocular diseases. Other key companies in the market include Sarepta Therapeutics Inc., Ionis Pharmaceuticals Inc. and Jazz Pharmaceuticals. In addition to therapeutics, oligonucleotide technology is also applied in diagnostics and research.
Report Scope
The report provides an overview of the oligonucleotides market and analyzes market trends. It includes global revenue ($ Million) for the base year 2024, estimated data for 2025 and forecast data from 2026 through 2030. The market is segmented by product type, application and region.
By product type, the market is segmented into oligonucleotide drugs, synthesized oligos, equipment and reagents, and services. The application segment is characterized by research and therapeutics and diagnostics. The report also includes an overview of the regulatory landscape for oligonucleotides.
The report also focuses on the regional segmentation of the market. The regions covered in this study include North America, Europe, the Asia-Pacific and the rest of the world (RoW), with a focus on major countries in these regions.
The report focuses on the major driving trends and challenges affecting the market and vendor landscape. It analyzes environmental, social and governance (ESG) developments and discusses emerging technologies related to the market. The report concludes with an analysis of the competitive landscape and industry structure. It also includes a dedicated section of company profiles, detailing leading market companies.
The report includes:
64 data tables and 55 additional tables
In-depth analysis of the global oligonucleotides market
Analyses of the global market trends, with historic revenue (sales data) from 2022 to 2024, estimates for 2025 and projections of CAGRs through 2030
Estimates of the current market size and revenue prospects for the global oligonucleotide synthesis market, accompanied by a market share analysis by product, application and region
Facts and figures pertaining to the global market dynamics, opportunities and deterrents, technological advancements, regulations, prospects and the impact of macroeconomic factors
Insights derived from Porter’s Five Forces model, as well as global supply chain analyses
Patent review, featuring key granted and published patents
Analysis of the industry structure, including companies’ market shares and rankings, product mappings, strategic initiatives, M&A activity and a venture funding outlook
Overview of sustainability trends and ESG developments, with emphasis on consumer attitudes, as well as the ESG risk ratings and practices of leading companies
Company profiles of major players within the industry, including Alnylam Pharmaceuticals Inc., Biogen/Ionis Pharmaceuticals Inc., Novartis AG, and Sarepta Therapeutics Inc
Company Profiles
Agilent Technologies Inc.
Ajinomoto Bio-Pharma
Alnylam Pharmaceuticals Inc.
Astellas Pharma Inc.
Biogen
Charles River Laboratories
Eurofins Genomics
Genscript
Integrated DNA Technologies Inc.
Merck KGaA
Novartis AG
Novo Nordisk A/S
Revvity
Sarepta Therapeutics Inc.
Thermo Fisher Scientific Inc.
Key Attributes:
Report Attribute
Details
No. of Pages
125
Forecast Period
2025 – 2030
Estimated Market Value (USD) in 2025
$9.1 Billion
Forecasted Market Value (USD) by 2030
$15.7 Billion
Compound Annual Growth Rate
11.5%
Regions Covered
Global
Key Topics Covered:
Chapter 1 Executive Summary
Chapter 2 Market Overview
Overview
Types of Oligonucleotides
Mechanisms of Action of Oligonucleotides
Oligonucleotide Synthesis Processes
Solid Phase Chemical Synthesis
Porter’s Five Forces Analysis in the Global Oligonucleotides Market
Macroeconomic Factor Analysis
Impact of the U.S. Tariffs
Growing Rare Disease Funding
Geopolitical Factors
Chapter 3 Market Dynamics
Market Dynamics
Market Drivers
Growing Focus on Personalized Medicine
Increasing Use of Synthesized Oligos in Therapeutic Applications
Rising Prevalence of Rare Diseases
Market Restraints/Challenges
Product Withdrawals and Clinical Trial Failures
Complexities Associated with Oligos Manufacturing
High Treatment Costs of Oligonucleotide Therapeutics
Market Opportunities
Expanding Application Areas of Oligonucleotides
Expansion of Companies
DNA Nanotechnology for Drug Delivery
Chapter 4 Regulatory Landscape
Chapter 5 Emerging Technologies
Key Takeaways
Emerging Technologies
Enzymatic Oligonucleotide Synthesis
Advances in RNAi Delivery Systems
Circulating miRNA Diagnostics for Noninvasive Health Monitoring
Innovative Oligonucleotide Conjugation Methods
Pipeline Analysis
Chapter 6 Market Segmentation Analysis
Segmentation Breakdown
Market Analysis by Product Type
Key Takeaways
Oligonucleotide Drugs
Synthesized Oligos
Equipment and Reagents
Services
Market Analysis by Application
Key Takeaways
Diagnostics and Therapeutics
Research
Geographic Breakdown
Market Analysis by Region
Key Takeaways
North America
Europe
Asia-Pacific
Rest of the World
Chapter 7 Competitive Intelligence
Chapter 8 Sustainability in the Global Oligonucleotides Market: An ESG Perspective
Introduction to ESG
ESG Risk Ratings
Conclusion
Chapter 9 Appendix
Methodology
Sources
Abbreviations
For more information about this report visit https://www.researchandmarkets.com/r/8zft3d
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