Present address: Roche Information Solutions (RIS) Data & Analytics, Roche Diagnostics, F. Hoffmann-La Roche Ltd., Basel, Switzerland

Present address: Chiesi Group, Manchester, United Kingdom

Present address: Computer Science Resource and Research Center, Institut Pasteur, Paris, France

Present address: Roche Innovation Center Basel, and Product Development Neuroscience, F. Hoffmann-La Roche Ltd., Basel, Switzerland

Present address: F. Hoffmann-La Roche Ltd, Basel, Switzerland

Present address: Biotech, Zurich, Switzerland

Present address: Granite Bio, Basel, Switzerland

Present address: Idorsia Pharmaceuticals, Allschwil, Switzerland

Present address: Bial, Trofu, Portugal

Present address: Vaxxinity Inc, Dallas, USA

Present address: Research Center Juelich, Juelich, Germany

Present address: Ardea Outcomes Inc, Halifax, Canada

Present address: Xaira Therapeutics, South San Francisco, USA

Present address: Gruenbauer Gmbh, Regenstauf, Germany

Present address: Novartis, Basel, Switzerland

Present address: Cview-consult gmbh, Basel, Switzerland

Present address: QurAlis, Cambridge, USA

Present address: SOBI, Basel, Switzerland

Present address: AC Immune, Geneva, Switzerland

Present address: Prevail Therapeutics, New York City, USA

Present address: Cogstate, Melbourne, Australia

Present address: xperimed gmbh, Basel, Switzerland

Present address: Lundbeck, Copenhagen, Denmark

These authors contributed equally: Kirsten I. Taylor, Florian Lipsmeier

K.I.T. wrote the first draft; K.I.T., F.L., W.P., T.Ki., J.S.-E., T.Ku., H.S., G.P. and M.L. aided in the conduct of the study; F.L., E.V.-V., D.R., M.A.S., D.S., J.A.-C., M.A., A.M., L.E. analyzed the data; K.I.T., F.L., E.V.-V., D.R., M.A.S., W.P., J.A.-C., M.A., L.E., T.Ku., H.S., T.N., R.B.P., G.P. and M.L. interpreted the results; K.I.T., F.L., E.V.-V., D.R., M.A.S., W.P., J.A.-C., M.A., T.Ki., S.L., J.S.-E., L.E., T.Ku., W.Z., H.S., T.N., R.B.P., G.P. and M.L. revised the manuscript. K.I.T. confirms that all authors have read and approved the manuscript.