{"id":11829,"date":"2026-02-18T15:34:08","date_gmt":"2026-02-18T15:34:08","guid":{"rendered":"https:\/\/www.europesays.com\/ch\/11829\/"},"modified":"2026-02-18T15:34:08","modified_gmt":"2026-02-18T15:34:08","slug":"unnatural-products-novartis-sign-licensing-agreement-for-cardiovascular-program","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/ch\/11829\/","title":{"rendered":"Unnatural Products, Novartis sign licensing agreement for cardiovascular program"},"content":{"rendered":"<p><a data-ylk=\"elm:icon;slk:Reuters;\" href=\"https:\/\/www.reuters.com\/\" target=\"_blank\" rel=\"nofollow noopener\"><img alt=\"Reuters\" loading=\"lazy\" width=\"171\" height=\"40\" decoding=\"async\" data-nimg=\"1\" class=\"pr-2.5 max-w-[150px] max-h-[40px] min-[601px]:max-w-[115px]\" style=\"color:transparent;max-width:auto;max-height:100%\" src=\"https:\/\/www.europesays.com\/ch\/wp-content\/uploads\/2026\/02\/62e21440-2fbd-11eb-95ff-5673fa3d2f9f.png\"\/><\/a>Wed, February 18, 2026 at 1:35 PM UTC<img alt=\"\" loading=\"lazy\" width=\"800\" height=\"533\" decoding=\"async\" data-nimg=\"1\" class=\"standard-img w-full w-full h-auto\" style=\"color:transparent\" src=\"https:\/\/www.europesays.com\/ch\/wp-content\/uploads\/2026\/02\/fe7bc77c55cdb7e8d27fd769bd419349.jpeg\"\/><\/p>\n<p>A sign marks the Novartis Institutes for BioMedical Research facility in Cambridge, Massachusetts, U.S., June 16, 2021. REUTERS\/Brian Snyder<\/p>\n<p>Feb 18 (Reuters) &#8211; Unnatural Products said on Wednesday it has \u200csigned a licensing agreement \u200cwith Novartis to develop macrocyclic peptide-based therapies \u200bfor a cardiovascular program.<\/p>\n<p>The California-based biotech company will receive up to $100 million in upfront payment \u200cand as \u2060much as $1.7 billion in development, regulatory, and commercial milestones. \u2060It will also be eligible for tiered royalties mid-single \u200bup to \u200blow double-digits \u200bon annual net \u200csales.<\/p>\n<p>The Swiss drugmaker will take the lead to oversee clinical development, manufacturing and global commercialization of any resulting drugs.<\/p>\n<p>The company did \u200cnot disclose the \u200bexact nature of \u200bthe program.<\/p>\n<p>Macrocyclic \u200bpeptides are a \u200cclass of therapeutic molecules \u200bshaped into \u200ba ring-like structure, which gives them advantages over traditional small-molecule \u200bdrugs \u200cand larger biologics.<\/p>\n<p>(Reporting by Siddhi \u200bMahatole in Bengaluru; Editing \u200bby Mrigank Dhaniwala)<\/p>\n","protected":false},"excerpt":{"rendered":"Wed, February 18, 2026 at 1:35 PM UTC A sign marks the Novartis Institutes for BioMedical Research facility&hellip;\n","protected":false},"author":2,"featured_media":681,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[127],"tags":[8789,8836,8786,206,8774],"class_list":{"0":"post-11829","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-novartis","8":"tag-biotech-company","9":"tag-cardiovascular-program","10":"tag-licensing-agreement","11":"tag-novartis","12":"tag-unnatural-products"},"share_on_mastodon":{"url":"","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/ch\/wp-json\/wp\/v2\/posts\/11829","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/ch\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/ch\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ch\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ch\/wp-json\/wp\/v2\/comments?post=11829"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/ch\/wp-json\/wp\/v2\/posts\/11829\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ch\/wp-json\/wp\/v2\/media\/681"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/ch\/wp-json\/wp\/v2\/media?parent=11829"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/ch\/wp-json\/wp\/v2\/categories?post=11829"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/ch\/wp-json\/wp\/v2\/tags?post=11829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}