{"id":113295,"date":"2026-06-10T10:58:20","date_gmt":"2026-06-10T10:58:20","guid":{"rendered":"https:\/\/www.europesays.com\/cz\/113295\/"},"modified":"2026-06-10T10:58:20","modified_gmt":"2026-06-10T10:58:20","slug":"osel-cz-opet-se-geneticky-modifikuji-lidska-embrya-a-tentokrat-je-v-hlavni-roli-cech","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/cz\/113295\/","title":{"rendered":":: OSEL.CZ :: – Op\u011bt se geneticky modifikuj\u00ed lidsk\u00e1 embrya. A tentokr\u00e1t je v hlavn\u00ed roli \u010cech."},"content":{"rendered":"

Op\u011bt se geneticky modifikuj\u00ed lidsk\u00e1 embrya. A tentokr\u00e1t je v hlavn\u00ed roli \u010cech. \u00a0<\/p>\n

Zat\u00edm jen ve form\u011b preprintu na platform\u011b bioRxiv zve\u0159ejnil t\u00fdm veden\u00fd Dieterem Eglim z\u00a0newyorsk\u00e9 Columbia University v\u00fdsledky experiment\u016f, p\u0159i nich\u017e v\u011bdci c\u00edlen\u011b upravili v\u00a0lidsk\u00fdch embry\u00edch trojici gen\u016f. Je kolem toho celkem poprask. Pro n\u00e1s m\u016f\u017ee cel\u00e1 kauza z\u00edskat na zaj\u00edmavosti i d\u00edky prvn\u00edmu autorovi studie \u0160t\u011bp\u00e1novi Je\u0159\u00e1bkovi, kter\u00fd se krom\u011b p\u016fsoben\u00ed na Columbia University hl\u00e1s\u00ed jako k\u00a0domovsk\u00e9 organizaci k\u00a0\u00dastavu organick\u00e9 chemie a biochemie AV \u010cR. Dal\u0161\u00ed \u010deskou stopu reprezentuje Marcos Iuri Roos Kulmann, kter\u00fd p\u016fsob\u00ed na \u00dastavu molekul\u00e1rn\u00ed genetiky AV \u010cR a na Karlov\u011b univerzit\u011b.<\/p>\n

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O co jde? Rozhodn\u011b ne o skand\u00e1l \u010d\u00ednsk\u00e9ho kalibru z\u00a0roku 2018, kdy \u010d\u00ednsk\u00fd biofyzik Jiankui He zas\u00e1hl do d\u011bdi\u010dn\u00e9 informace t\u0159\u00ed lidsk\u00fdch embry\u00ed, z\u00a0kter\u00fdch se narodily d\u011bti. \u010casopis Time za\u0159adil n\u00e1sleduj\u00edc\u00ed rok \u010c\u00ed\u0148ana mezi 100 nejvlivn\u011bj\u0161\u00edch lid\u00ed planety, ale odborn\u00fd sv\u011bt byl z\u00a0valn\u00e9 \u010d\u00e1sti zhnusen a \u010d\u00ednsk\u00e1 justice mu vym\u011b\u0159ila za poru\u0161en\u00ed z\u00e1kon\u016f 3 a p\u016fl roku natvrdo. (OSEL o t\u011bchto \u010d\u00ednsk\u00fdch pokusech informoval nap\u0159\u00edklad\u00a0zde<\/a>, \u00a0zde<\/a> a zde<\/a>).<\/p>\n

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D\u016fvod odsuzuj\u00edc\u00edch reakc\u00ed je celkem prost\u00fd. Jiankui He pou\u017eil pro z\u00e1sah do d\u011bdi\u010dn\u00e9 informace technologii CRISPR-Cas9 a ta je pro tyto \u00fa\u010dely m\u00e1lo spolehliv\u00e1. M\u016f\u017ee v\u00a0d\u011bdi\u010dn\u00e9 informaci embrya nap\u00e1chat v\u00edc \u0161kody ne\u017e u\u017eitku. Jasn\u011b se to uk\u00e1zalo nap\u0159. v\u00a0experimentech, kdy se v\u011bdci z\u00a0t\u00fdmu \u0160ukrata Mitalipova pokusili v\u00a0oplozen\u00e9m vaj\u00ed\u010dku korigovat vadn\u00fd gen a v\u00fdsledkem byly ztr\u00e1ty rozs\u00e1hl\u00fdch oblast\u00ed genomu v\u00a0takto vznikl\u00fdch embry\u00edch. To byly d\u016fvody, pro\u010d \u0160t\u011bp\u00e1n Je\u0159\u00e1bek p\u0159istoupil k\u00a0z\u00e1sah\u016fm do d\u011bdi\u010dn\u00e9 informace lidsk\u00fdch embry\u00ed \u00fapln\u011b jinak. Rozhodl se pro tzv. base editing, co\u017e je crisprov\u00e1 technologie druh\u00e9 generace.<\/p>\n

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\n\"\u0160t\u011bp\u00e1n<\/p>\n

\u0160t\u011bp\u00e1n Je\u0159\u00e1bek. Zdroj: ASPEN Institute.<\/p>\n


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\u0160t\u011bp\u00e1n Je\u0159\u00e1bek\u00a0je v\u011bdeck\u00fd pracovn\u00edk na Kolumbijsk\u00e9 univerzit\u011b v New Yorku.<\/p>\n

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\u0160t\u011bp\u00e1n p\u016fsob\u00ed tak\u00e9 v \u00dastavu organick\u00e9 chemie a biochemie v Praze. Jeho sou\u010dasn\u00e1 v\u011bdeck\u00e1 pr\u00e1ce se zam\u011b\u0159uje na identifikaci faktor\u016f, kter\u00e9 zm\u00edr\u0148uj\u00ed replika\u010dn\u00ed stres v ran\u00e9m lidsk\u00e9m v\u00fdvoji. <\/p>\n

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Zab\u00fdv\u00e1 se hodnocen\u00edm bezpe\u010dnosti a proveditelnosti prevence z\u00e1va\u017en\u00fdch genetick\u00fdch onemocn\u011bn\u00ed pomoc\u00ed genov\u00e9 terapie.<\/p>\n


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\u0160t\u011bp\u00e1n absolvoval Vysokou \u0161kolu chemicko-technologickou v Praze. Jeho doktorsk\u00e9 studium v \u200b\u200bN\u011bmecku bylo podpo\u0159eno grantem od Spole\u010dnosti Maxe Plancka. Je b\u00fdval\u00fdm postdoktorandem na Harvard Medical School.\u00a0Foto kredit: \u0160t\u011bp\u00e1n Je\u0159\u00e1bek.<\/p>\n

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\u0160t\u011bp\u00e1novi k \u00fasp\u011bchu zhmotn\u011bn\u00e9mu v publikaci na<\/p>\n

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bioRxiv, 2026-05 p\u0159ipojujeme Osl\u00ed gratulaci!<\/p>\n

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Od CRISPR k\u00a0base editingu<\/p>\n

Klasick\u00fd CRISPR funguje jako molekul\u00e1rn\u00ed n\u016f\u017eky, kter\u00e9 na vybran\u00e9m m\u00edst\u011b p\u0159est\u0159ihnou ob\u011b vl\u00e1kna dvojit\u00e9 \u0161roubovice DNA a na tomto m\u00edst\u011b pak prob\u011bhne po\u017eadovan\u00e1 zm\u011bna \u2013 po\u0161kozen\u00ed genu, vlo\u017een\u00ed nov\u00e9 sekvence, z\u00e1m\u011bna sekvenc\u00ed\u2026 N\u011bkter\u00e9 varianty CRISPR p\u0159est\u0159ihnou p\u0159i navozen\u00ed stejn\u00fdch zm\u011bn jen jedno vl\u00e1kno dvojit\u00e9 \u0161roubovice. Nic z\u00a0toho ale nen\u00ed bez rizika. Ke st\u0159ih\u016fm toti\u017e m\u016f\u017ee doch\u00e1zet i mimo c\u00edlov\u00e9 m\u00edsto, co\u017e hroz\u00ed vznikem genetick\u00e9ho defektu. Zd\u00e1 se, \u017ee d\u011bdi\u010dn\u00e1 informace lidsk\u00e9ho embrya je k\u00a0takov\u00fdm \u201enec\u00edlov\u00fdm st\u0159ih\u016fm\u201c zvl\u00e1\u0161t\u011b n\u00e1chyln\u00e1.<\/p>\n

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P\u0159i base editingu nen\u00ed dvojit\u00e1 \u0161roubovice st\u0159\u00edh\u00e1na. Na vybran\u00e9 m\u00edsto d\u011bdi\u010dn\u00e9 informace je dopraven enzym, kter\u00fd katalyzuje biochemickou reakci, a tou se m\u011bn\u00ed jedno p\u00edsmeno genetick\u00e9ho k\u00f3du na jin\u00e9 p\u00edsmeno. Je\u0159\u00e1bek pou\u017eil enzym, kter\u00fd m\u011bn\u00ed adenin na guanin. Base editingem pak navodil zm\u011bny ve t\u0159ech genech lidsk\u00fdch embry\u00ed. V\u00a0genu PCSK9 vytvo\u0159il \u201ete\u010dku\u201c, kter\u00e1 nedovol\u00ed, aby se podle genu vyrobila p\u0159\u00edslu\u0161n\u00e1 b\u00edlkovina. Gen PCSK9 hraje d\u016fle\u017eitou roli v\u00a0metabolismu cholesterolu. Jeho vy\u0159azen\u00edm z\u00a0\u010dinnosti lze sn\u00ed\u017eit hladiny cholesterolu v\u00a0krvi u lid\u00ed, kter\u00e9 ohro\u017euj\u00ed extr\u00e9mn\u011b vysok\u00e9 hodnoty cholesterolu a nezab\u00edraj\u00ed jim l\u00e9ky.<\/p>\n

D\u00e1le se Je\u0159\u00e1bek a spol. zam\u011b\u0159ili na geny HBG1 a HBG2. Ty k\u00f3duj\u00ed tzv. fet\u00e1ln\u00ed hemoglobin obsa\u017een\u00fd v \u010derven\u00fdch krvink\u00e1ch lidsk\u00e9ho embrya a plodu. Po narozen\u00ed jsou tyto geny \u201eusp\u00e1ny\u201c a fet\u00e1ln\u00ed hemoglobin je v\u00a0\u010derven\u00fdch krvink\u00e1ch nahrazen \u201edosp\u011bl\u00fdm\u201c hemoglobinem A. Pokud m\u00e1 \u010dlov\u011bk po\u0161kozen n\u011bkter\u00fd z\u00a0gen\u016f pro tvorbu dosp\u011bl\u00e9ho hemoglobinu A, m\u016f\u017ee trp\u011bt d\u011bdi\u010dn\u00fdmi chorobami, jako je srpkovit\u00e1 an\u00e9mie, beta-talasemie aj.<\/p>\n

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Dnes u\u017e se vyv\u00edjej\u00ed v\u00a0r\u00e1mci tzv. genov\u00fdch terapi\u00ed z\u00e1sahy do d\u011bdi\u010dn\u00e9 informace t\u011bln\u00edch bun\u011bk pacient\u016f pomoc\u00ed CRISPR, kter\u00e9 c\u00edl\u00ed na l\u00e9\u010dbu vysok\u00fdch hladin cholesterolu blokov\u00e1n\u00edm genu PCSK9. Obnova tvorby fet\u00e1ln\u00edho hemoglobinu genovou terapi\u00ed Casgevy u\u017e byla schv\u00e1lena jak pro l\u00e9\u010dbu srpkovit\u00e9 anemie, tak i beta-talasemie. \u0160t\u011bp\u00e1n Je\u0159\u00e1bek se rozhodl uk\u00e1zat, jak by podobn\u00e9 z\u00e1sahy s\u00a0vyu\u017eit\u00edm base editingu zab\u00edraly v\u00a0lidsk\u00e9m embryu. V\u00fdsledky jsou bezesporu zaj\u00edmav\u00e9. Z\u00e1rove\u0148 ale nejsou nijak povzbudiv\u00e9. I base editing m\u00e1 p\u0159i \u00faprav\u011b d\u011bdi\u010dn\u00e9 informace lidsk\u00fdch embry\u00ed sv\u00e9 limity.<\/p>\n

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\n\"Dieter<\/a><\/p>\n

Dieter Egli. Zdroj: Columbia Univ.<\/p>\n


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Dieter Egli z\u00edskal doktor\u00e1t na Univerzit\u011b v Curychu ve \u0160v\u00fdcarsku a postdoktorandsk\u00e9 studium absolvoval na Harvardov\u011b univerzit\u011b.<\/p>\n


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V roce 2008 Egli nastoupil do v\u00fdzkumn\u00e9ho \u00fastavu New York Stem Cell Foundation Research Institute jako v\u011bdeck\u00fd pracovn\u00edk. <\/p>\n

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Nyn\u00ed p\u016fsob\u00ed na Kolumbijsk\u00e9 univerzit\u011b a v Centru pro diabetes Naomi Berrie a v Columbia Stem Cell Initiative.<\/p>\n


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Jeho skupina studuje stabilitu genomu v ran\u00e9m v\u00fdvoji, diferenciaci a reprogramov\u00e1n\u00ed a upozor\u0148uje na obt\u00ed\u017en\u011b replikovateln\u00e1 m\u00edsta v genomu, kter\u00e1 \u010dasto vedou k p\u0159eru\u0161en\u00ed DNA, genetick\u00fdm zm\u011bn\u00e1m a v\u00fdvojov\u00e9mu selh\u00e1n\u00ed v ran\u00e9 f\u00e1zi lidsk\u00e9ho v\u00fdvoje.<\/p>\n


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Kredit: Columbia University, Irving Medical Center. <\/p>\n


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Komplikace base editingu<\/p>\n

Jedn\u00edm z\u00a0limit\u016f, na kter\u00fd t\u00fdm narazil, je mozaicismus. To znamen\u00e1, \u017ee z\u00e1sah do DNA pomoc\u00ed base editingu se neprojevil ve v\u0161ech bu\u0148k\u00e1ch embrya. N\u011bkde z\u016fstala p\u016fvodn\u00ed konfigurace DNA a p\u00edsmeno genetick\u00e9ho k\u00f3du adenin se nep\u0159epsalo na guanin. To je nep\u0159\u00edjemn\u00e9, proto\u017ee v\u00a0dal\u0161\u00edm v\u00fdvoji se mohou bu\u0148ky s\u00a0nezm\u011bn\u011bnou d\u011bdi\u010dnou informac\u00ed pod\u00edlet na stavb\u011b tk\u00e1n\u00ed a org\u00e1n\u016f. Choroba, jako je vysok\u00fd cholesterol, srpkovit\u00e1 anemie nebo beta-talasemie, se pak m\u016f\u017ee r\u016fznou m\u011brou p\u0159eci jen projevit.<\/p>\n

Tak\u00e9 se uk\u00e1zalo, \u017ee z\u00e1sah base editingem je pom\u011brn\u011b komplikovan\u00fd. V\u011bdc\u016fm se nab\u00edz\u00ed, aby ho do embrya vnesli v\u00a0podob\u011b kyseliny ribonukleov\u00e9 (RNA) a ponechali embryo, aby si pot\u0159ebn\u00e9 b\u00edlkovinn\u00e9 n\u00e1stroje pro tyto \u00fa\u010dely samo vytvo\u0159ilo podle dodan\u00e9 RNA. Jen\u017ee v\u00a0tomto p\u0159\u00edpad\u011b reaguj\u00ed embrya na d\u00e1vku RNA zastaven\u00edm v\u00fdvoje. L\u00e9pe se jim vedlo, kdy\u017e do nich v\u011bdci dodali n\u00e1stroj pro base editing hotov\u00fd ve form\u011b proteinu. V\u00fdroba takov\u00e9ho n\u00e1stroje je ale mnohem komplikovan\u011bj\u0161\u00ed a tak\u00e9 dra\u017e\u0161\u00ed.<\/p>\n

D\u016fle\u017eit\u00e9 je i zji\u0161t\u011bn\u00ed, \u017ee i base editing m\u011bl \u201enec\u00edlov\u00e9 z\u00e1sahy\u201c. Tam, kde m\u011bl CRISPR tendenci k\u00a0nec\u00edlov\u00fdm st\u0159ih\u016fm, tam podobn\u011b konstruovan\u00fd n\u00e1stroj pro base editing p\u0159episoval \u201enav\u00edc\u201c adeniny na guaniny. Tak\u00e9 to je ne\u017e\u00e1douc\u00ed vedlej\u0161\u00ed efekt.<\/p>\n

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\n\"Zdroj:<\/a><\/p>\n


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Abstrakt nejnov\u011bj\u0161\u00edch v\u00fdsledk\u016f Egliho t\u00fdmu t\u00fdkaj\u00edc\u00ed se editace gen\u016f pomoc\u00ed ABE po injekci do lidsk\u00fdch zygot.<\/p>\n

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a, Schematick\u00e9 zn\u00e1zorn\u011bn\u00ed genomov\u00e9 lokalizace dvou c\u00edlov\u00fdch gen\u016f,\u00a0PCSK9 a\u00a0HBG1\/2 , a sekvenc\u00ed pou\u017eit\u00fdch sgRNA.<\/p>\n

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b, Pracovn\u00ed postup pro dod\u00e1n\u00ed mRNA ABE nebo ribonukleoproteinu ABE (RNP) do dvoupronukle\u00e1rn\u00edch (2PN) lidsk\u00fdch zygot a anal\u00fdza vzork\u016f amplifikovan\u00fdch cel\u00fdm genomem (WGA) z jednotliv\u00fdch bun\u011bk odebran\u00fdch z injikovan\u00fdch embry\u00ed.\u00a0ce, Sangerovy sekven\u010dn\u00ed chromatogramy zobrazuj\u00edc\u00ed v\u00fdsledky editace b\u00e1z\u00ed ve dvou c\u00edlov\u00fdch lokusech,\u00a0PCSK9 (\u00a0c ) a\u00a0HBG1\/2 (\u00a0d, e ). Dva typy inzerc\u00ed detekovan\u00e9 v\u00a0HBG1\/2 jsou zn\u00e1zorn\u011bny (\u00a0e ) pomoc\u00ed Sangerov\u00fdch sekven\u010dn\u00edch chromatogram\u016f a nukleotidov\u00fdch sekvenc\u00ed b\u00e1z\u00ed podle anal\u00fdzy s pou\u017eit\u00edm EditR\u00a048. f, g, Kvantifikace\u00a0v\u00fdsledk\u016f editace na z\u00e1klad\u011b Sangerova sekvenov\u00e1n\u00ed jednotliv\u00fdch bun\u011bk izolovan\u00fdch z lidsk\u00fdch embry\u00ed\u00a0upraven\u00fdch mRNA ABE (\u00a0f ) a RNP (\u00a0g ). Cel\u00e1 pr\u00e1ce je p\u0159\u00edstupn\u00e1 zde<\/a>. Zdroj: Jerabek, S., et al. 2026<\/a>.<\/p>\n


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Obavy kritik\u016f<\/p>\n

Koment\u00e1\u0159 na webu \u010dasopisu Nature dal slovo kritik\u016fm, kte\u0159\u00ed Egliho, Je\u0159\u00e1bka a dal\u0161\u00ed \u010dleny t\u00fdmu obvinili z\u00a0rozjezdu vylep\u0161ov\u00e1n\u00ed \u010dlov\u011bka.<\/p>\n

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\"Fjodor<\/a><\/p>\n

Fjodor Urnov je \u0159editelem terapeutick\u00e9ho v\u00fdzkumu a v\u00fdvoje na Inovative Genomics Institute, jeho\u017e zam\u011b\u0159en\u00edm je l\u00e9\u010dba v kojeneck\u00e9m v\u011bku zalo\u017een\u00e1 na platform\u011b CRISPR. Spolu s Centrem pro pediatrick\u00e9 CRISPR Cures se sna\u017e\u00ed vytvo\u0159it platformu \u0161k\u00e1lovateln\u00fdch terapi\u00ed za dostupnou cenu. Kredit: Inovative Genomics.<\/p>\n

\u201eV praxi tento preprint ovlivn\u00ed pouze rychle rostouc\u00ed hnut\u00ed editor\u016f embry\u00ed za \u00fa\u010delem \u201evylep\u0161en\u00ed d\u00edt\u011bte\u201c,\u201c \u0159\u00edk\u00e1 nap\u0159\u00edklad Fjodor Urnov, kter\u00fd se zab\u00fdv\u00e1 genov\u00fdmi terapiemi na University of California v\u00a0Berkeley. Urnov m\u00e1 na sv\u00e9m kont\u011b v\u00fdvoj star\u0161\u00edho n\u00e1stroje pro c\u00edlen\u00e9 \u00fapravy DNA, tzv. zinc finger nucleases, a CRISPR a dal\u0161\u00ed \u201ekonkuren\u010dn\u00ed novoty\u201c nem\u00e1 moc v\u00a0l\u00e1sce.<\/p>\n

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\u201eJsem z toho velmi znepokojen,\u201c \u0159\u00edk\u00e1 Stuart Newman, v\u00fdvojov\u00fd biolog z\u00a0New York Medical College. \u201ePoka\u017ed\u00e9, kdy\u017e se podnikne takov\u00fd krok, tak se podobn\u00e9 v\u011bci st\u00e1vaj\u00ed norm\u00e1ln\u011bj\u0161\u00edmi. Lid\u00e9 si na to zvyknou.\u201c<\/p>\n

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Eglimu ale d\u00e1v\u00e1 smysl upravovat DNA embrya a ne\u010dekat na opravu genetick\u00fdch abnormalit, a\u017e kdy\u017e jedinec pln\u011b dosp\u011bje. V\u00a0dosp\u011blosti si jedinec nese defekt v\u00a0obrovsk\u00e9m mno\u017estv\u00ed bun\u011bk a ty u\u017e v\u0161echny odstranit nelze. Po\u0161kozen\u00ed DNA z\u016fstane nap\u0159\u00edklad v\u00a0pohlavn\u00edch bu\u0148k\u00e1ch a posti\u017een\u00fd \u010dlov\u011bk bude p\u0159en\u00e1\u0161et defekt na sv\u00e9 potomky.<\/p>\n

\u201eP\u0159i \u00faprav\u011b embry\u00ed m\u00e1te jednu kopii, a tu oprav\u00edte,\u201c vysv\u011btluje Egli.<\/p>\n

Dieter Egli vid\u00ed hlavn\u00ed motiv pro podobn\u00fd v\u00fdzkum v\u00a0nal\u00e9hav\u00e9 pot\u0159eb\u011b l\u00e9pe porozum\u011bt procesu opravy DNA v lidsk\u00fdch embry\u00edch, proto\u017ee ty prob\u00edhaj\u00ed za jin\u00fdch podm\u00ednek ne\u017e v pozd\u011bj\u0161\u00edch f\u00e1z\u00edch lidsk\u00e9ho \u017eivota. V\u011b\u0159\u00ed, \u017ee techniky pro z\u00e1sahy do DNA lidsk\u00fdch embry\u00ed lze v\u00fdrazn\u011b vylep\u0161it. V\u011bdci z\u00a0jeho t\u00fdmu u\u017e zdokonalili metody base editingu u embry\u00ed a sn\u00ed\u017eili t\u00edm v\u00fdskyt mozaicismu. P\u0159esto nepova\u017euj\u00ed tuto technologii za zralou pro klinick\u00e9 pou\u017eit\u00ed.<\/p>\n

\u201eSt\u00e1vaj\u00edc\u00ed DNA editory mohou m\u00edt \u0161kodliv\u00e9 dopady na embryo. V sou\u010dasn\u00e9 podob\u011b je nem\u016f\u017eete pou\u017e\u00edt. Je to jasn\u00e9 jako den a noc,\u201c \u0159\u00edk\u00e1 Egli.<\/p>\n

\u00a0<\/p>\n

Co podniknou soukrom\u00e9 firmy?<\/p>\n

Jako kontroverzn\u00ed vid\u00ed mnoz\u00ed zapojen\u00ed\u00a0newyorsk\u00e9 firmy Nucleus Genomics. Ta se zab\u00fdv\u00e1 l\u00e9\u010dbou neplodnosti in vitro oplozen\u00edm a vyu\u017e\u00edv\u00e1 p\u0159itom genetick\u00fdch test\u016f embry\u00ed. C\u00edlem t\u011bchto postup\u016f je vybrat z\u00a0n\u011bkolika z\u00edskan\u00fdch embry\u00ed to (nebo ta), kter\u00e9(\u00e1) zd\u011bdilo(a) od rodi\u010d\u016f nejlep\u0161\u00ed kombinaci gen\u016f. Embrya mohou samoz\u0159ejm\u011b zd\u011bdit jen ty varianty gen\u016f, kter\u00fdmi disponuj\u00ed ve sv\u00e9 DNA jejich biologi\u010dt\u00ed rodi\u010de. N\u011bkte\u0159\u00ed bioetici se ob\u00e1vaj\u00ed, \u017ee v\u00a0p\u0159\u00edpad\u011b, kdy embryo nebude m\u00edt v\u0161echny pot\u0159ebn\u00e9 vlohy, firmy jim je dodaj\u00ed t\u0159eba pr\u00e1v\u011b pomoc\u00ed base editingu.<\/p>\n

Egli ale zd\u016fraz\u0148uje, \u017ee je z\u00e1sadn\u011b proti takzvan\u00e9mu \u201evylep\u0161ov\u00e1n\u00ed\u201c embry\u00ed a \u017ee kvalitn\u00ed v\u00fdzkum tuto praxi zastav\u00ed.<\/p>\n

\u201eV\u00fdzkum je nezbytn\u00fd k tomu, aby poskytoval informace, kter\u00e9 odrazuj\u00ed od nespr\u00e1vn\u00e9ho pou\u017e\u00edv\u00e1n\u00ed technologie,\u201c \u0159\u00edk\u00e1 Egli.<\/p>\n

\u00a0<\/p>\n

Kian Sadeghi z\u00a0Nucleus Genomics pova\u017euje roz\u0161\u00ed\u0159en\u00ed nab\u00eddky slu\u017eeb o genetick\u00e9 \u00fapravy embry\u00ed sice za dal\u0161\u00ed logick\u00fd krok, ale z\u00e1rove\u0148 to vid\u00ed jako velmi vzd\u00e1len\u00fd c\u00edl.<\/p>\n

\u201eJde n\u00e1m st\u00e1le o jedno. Chceme p\u0159isp\u011bt k tomu, aby pacienti \u010dinili informovan\u011bj\u0161\u00ed reproduk\u010dn\u00ed rozhodnut\u00ed, aby m\u011bli zdrav\u011bj\u0161\u00ed d\u00edt\u011b,\u201c \u0159\u00edk\u00e1 Sadeghi.<\/p>\n

Sadeghi o\u010dek\u00e1v\u00e1, \u017ee editace DNA embry\u00ed bude specializovanou slu\u017ebou pro lidi, kte\u0159\u00ed se ob\u00e1vaj\u00ed p\u0159enosu genetick\u00fdch poruch na sv\u00e9 d\u011bti a kte\u0159\u00ed nemaj\u00ed dostatek zdrav\u00fdch embry\u00ed pro embryon\u00e1ln\u00ed selekci. Editace embry\u00ed zac\u00edlen\u00e1 na vlastnosti, jako je inteligence nebo t\u011blesn\u00e1 v\u00fd\u0161ka, je podle Sadeghiho v sou\u010dasn\u00e9 dob\u011b nepraktick\u00e1.<\/p>\n

\u201eTyto vlastnosti jsou geneticky zalo\u017eeny velmi slo\u017eit\u011b a jsou ovlivn\u011bny kombinovan\u00fdm p\u016fsoben\u00edm mnoha gen\u016f, tak\u017ee editace b\u00e1z\u00ed by nebyla provediteln\u00e1,\u201c \u0159\u00edk\u00e1 Sadeghi.<\/p>\n

\u00a0<\/p>\n

Redakce si dovolila p\u0159ipojit autorovo video \u201eO genetick\u00e9 revoluci, kter\u00e1 zm\u011bn\u00ed lidstvo nav\u017edy\u201c<\/p>\n

\u00a0<\/p>\n

\u00a0<\/p>\n

Prameny:<\/p>\n

Basu M., et al. (2026) Precise genome editing of human embryos triggers praise and alarm. Nature https:\/\/www.nature.com\/articles\/d41586-026-01827-8<\/a><\/p>\n

Jerabek, S., et al. (2026). Efficient base editing and development in human embryos without chromosomal alterations.\u00a0bioRxiv, 2026-05.<\/p>\n

Liang, D., et al. (2023). Limitations of gene editing assessments in human preimplantation embryos.\u00a0Nature Communications,\u00a014(1), 1219.<\/p>\n

Mills, P. (2019). Preimplantation genome editing: CCR5 in China.\u00a0Emerging Topics in Life Sciences,\u00a03(6), 695-700.<\/p>\n","protected":false},"excerpt":{"rendered":"Op\u011bt se geneticky modifikuj\u00ed lidsk\u00e1 embrya. A tentokr\u00e1t je v hlavn\u00ed roli \u010cech. \u00a0 Zat\u00edm jen ve form\u011b…\n","protected":false},"author":2,"featured_media":113296,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_share_on_mastodon":"0"},"categories":[11],"tags":[32374,32375,54,53,52],"class_list":["post-113295","post","type-post","status-publish","format-standard","has-post-thumbnail","category-svet","tag-crispr","tag-embryo","tag-svet","tag-world","tag-world-news"],"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@cz\/116725462334028447","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/posts\/113295","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/comments?post=113295"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/posts\/113295\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/media\/113296"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/media?parent=113295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/categories?post=113295"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/tags?post=113295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}