{"id":47475,"date":"2026-04-07T04:39:10","date_gmt":"2026-04-07T04:39:10","guid":{"rendered":"https:\/\/www.europesays.com\/cz\/47475\/"},"modified":"2026-04-07T04:39:10","modified_gmt":"2026-04-07T04:39:10","slug":"nova-studie-k-injekcim-na-hubnuti-mohou-zvysovat-riziko-poraneni-kosti-a-slach","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/cz\/47475\/","title":{"rendered":"Nov\u00e1 studie k\u00a0injekc\u00edm na hubnut\u00ed: mohou zvy\u0161ovat riziko poran\u011bn\u00ed kost\u00ed a\u00a0\u0161lach"},"content":{"rendered":"

Studie<\/a> nazna\u010duje, \u017ee l\u00e9ky na hubnut\u00ed ze skupiny GLP-1\u00a0mohou zvy\u0161ovat riziko poran\u011bn\u00ed kost\u00ed a\u00a0\u0161lach i\u00a0riziko rozvoje onemocn\u011bn\u00ed osteopor\u00f3zou \u010di dnou.<\/p>\n

V anal\u00fdze t\u00e9m\u011b\u0159 150\u00a0000\u00a0pacient\u016f v\u00fdzkumn\u00edci zjistili, \u017ee lid\u00e9 u\u017e\u00edvaj\u00edc\u00ed l\u00e9ky GLP-1\u00a0\u010delili v\u00fdrazn\u011b vy\u0161\u0161\u00edmu riziku onemocn\u011bn\u00ed kost\u00ed. B\u011bhem p\u011bti let bylo riziko osteopor\u00f3zy\u00a0\u2013 onemocn\u011bn\u00ed, kter\u00e9 oslabuje kosti a\u00a0\u010din\u00ed je k\u0159ehk\u00fdmi\u00a0\u2013 t\u00e9m\u011b\u0159 o\u00a030\u00a0procent vy\u0161\u0161\u00ed. Riziko dny, bolestiv\u00e9 z\u00e1n\u011btliv\u00e9 artritidy vznikaj\u00edc\u00ed tvorbou jehli\u010dkovit\u00fdch krystal\u016f v\u00a0kloubech, vzrostlo o\u00a012\u00a0procent. A\u00a0riziko osteomal\u00e1cie, tedy zm\u011bk\u010den\u00ed kost\u00ed zp\u016fsoben\u00e9ho nedostatkem miner\u00e1l\u016f, se zv\u00fd\u0161ilo o\u00a0v\u00edce ne\u017e 150\u00a0procent.<\/p>\n

\u201eBylo to mnohem v\u00edc, ne\u017e jsem \u010dekal,\u201c \u0159ekl den\u00edku The Washington Post (WP)<\/a> John Gabriel Horneff, jeden z\u00a0autor\u016f studie a\u00a0docent klinick\u00e9 ortopedick\u00e9 chirurgie na Pensylv\u00e1nsk\u00e9 univerzit\u011b.<\/p>\n

<\/a><\/p>\n

Clifford Rosen, profesor medic\u00edny na Tuftsov\u011b univerzit\u011b, kter\u00fd se studie ne\u00fa\u010dastnil, WP \u0159ekl, \u017ee p\u0159i milionech lid\u00ed, kte\u0159\u00ed nyn\u00ed tyto l\u00e9ky u\u017e\u00edvaj\u00ed, je celkov\u00e9 riziko na \u00farovni populace mal\u00e9. Pro jednotlivce v\u0161ak m\u016f\u017ee b\u00fdt i\u00a0m\u00edrn\u00e9 zv\u00fd\u0161en\u00ed rizika v\u00fdznamn\u00e9.<\/p>\n

U star\u0161\u00edch lid\u00ed m\u016f\u017ee nap\u0159\u00edklad zlomenina spustit \u0159et\u011bzec komplikac\u00ed, ze kter\u00fdch se n\u011bkte\u0159\u00ed u\u017e nikdy pln\u011b nevzpamatuj\u00ed. Tak\u00e9 \u017eeny po menopauze mohou b\u00fdt obzvl\u00e1\u0161\u0165 zraniteln\u00e9\u00a0\u2013 v\u00a0prvn\u00edch letech po p\u0159echodu se jejich riziko zlomeniny zvy\u0161uje asi o\u00a0jedno\u00a0a\u017e dv\u011b\u00a0procenta ro\u010dn\u011b. \u201eP\u0159idat k\u00a0tomu je\u0161t\u011b dal\u0161\u00ed procento m\u016f\u017ee b\u00fdt zni\u010duj\u00edc\u00ed,\u201c \u0159ekl Rosen, kter\u00fd t\u00e9\u017e zkoum\u00e1 vztah mezi l\u00e9ky GLP-1\u00a0a\u00a0zdrav\u00edm kost\u00ed.<\/p>\n

<\/a><\/p>\n

Studie byla prezentov\u00e1na pouze jako abstrakt a\u00a0zat\u00edm nepro\u0161la odborn\u00fdm recenzn\u00edm \u0159\u00edzen\u00edm. Ukazuje, kdy pacienti za\u010dali l\u00e9\u010dbu GLP-1, ale neuv\u00e1d\u00ed d\u00e1vkov\u00e1n\u00ed ani d\u00e9lku l\u00e9\u010dby. V\u00fdzkumn\u00edci p\u0159itom zohlednili v\u011bk, pohlav\u00ed, rasu, u\u017e\u00edv\u00e1n\u00ed tab\u00e1ku a\u00a0\u0159adu zdravotn\u00edch stav\u016f. Stejn\u011b jako jin\u00e9 observa\u010dn\u00ed studie nem\u016f\u017ee prok\u00e1zat p\u0159\u00ed\u010dinnou souvislost, pouze souvislost (asociaci).<\/p>\n

Pro\u010d by mohly kosti sl\u00e1bnout<\/p>\n

Jedna z\u00a0hypot\u00e9z je, \u017ee l\u00e9ky GLP-1\u00a0mohou ovliv\u0148ovat hormony d\u016fle\u017eit\u00e9 pro metabolismus kost\u00ed. Jin\u00e1 vysv\u011btlen\u00ed souvisej\u00ed p\u0159\u00edmo s\u00a0hubnut\u00edm. Sn\u00ed\u017een\u00e1 chu\u0165 k\u00a0j\u00eddlu m\u016f\u017ee v\u00e9st k\u00a0nedostatku \u017eivin\u00a0\u2013 p\u0159i nedostatku miner\u00e1l\u016f se kosti h\u016f\u0159e obnovuj\u00ed.<\/p>\n

Existuje i\u00a0jednodu\u0161\u0161\u00ed fyzik\u00e1ln\u00ed vysv\u011btlen\u00ed. Pokud n\u011bkdo dlouhodob\u011b v\u00e1\u017eil nap\u0159\u00edklad p\u0159es 130\u00a0kg a\u00a0rychle zhubne, zm\u011bn\u00ed se mechanick\u00e9 zat\u00ed\u017een\u00ed kost\u00ed. \u201eNajednou nejsou vystaveny stejn\u00e9 gravita\u010dn\u00ed z\u00e1t\u011b\u017ei,\u201c \u0159ekl Horneff. N\u00e1hl\u00e9 sn\u00ed\u017een\u00ed mechanick\u00e9 z\u00e1t\u011b\u017ee tak m\u016f\u017ee naru\u0161it rovnov\u00e1hu mezi rozpadem a\u00a0obnovou kostn\u00ed tk\u00e1n\u011b.<\/p>\n

Rosen uvedl, \u017ee data ka\u017edop\u00e1dn\u011b nazna\u010duj\u00ed, \u017ee dopad na kosti m\u016f\u017ee b\u00fdt v\u011bt\u0161\u00ed, ne\u017e se p\u0159edpokl\u00e1dalo, a\u00a0dodal, \u017ee farmaceutick\u00e9 firmy u\u017e vyv\u00edjej\u00ed nov\u00e9 verze t\u011bchto l\u00e9k\u016f, kter\u00e9 by \u00fabytek kostn\u00ed hmoty omezily.<\/p>\n

<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Studie nazna\u010duje, \u017ee l\u00e9ky na hubnut\u00ed ze skupiny GLP-1\u00a0mohou zvy\u0161ovat riziko poran\u011bn\u00ed kost\u00ed a\u00a0\u0161lach i\u00a0riziko rozvoje onemocn\u011bn\u00ed osteopor\u00f3zou…\n","protected":false},"author":2,"featured_media":47476,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[43,42,41,40,17794,1617,9903,17917,7604],"class_list":{"0":"post-47475","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-cesko","8":"tag-ceska-republika","9":"tag-cesko","10":"tag-czech-republic","11":"tag-czechia","12":"tag-kosti","13":"tag-leky","14":"tag-leky-na-hubnuti","15":"tag-osteoporoza","16":"tag-ozempic"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@cz\/116361583842048878","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/posts\/47475","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/comments?post=47475"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/posts\/47475\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/media\/47476"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/media?parent=47475"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/categories?post=47475"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/tags?post=47475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}