{"id":87634,"date":"2026-05-16T12:57:23","date_gmt":"2026-05-16T12:57:23","guid":{"rendered":"https:\/\/www.europesays.com\/cz\/87634\/"},"modified":"2026-05-16T12:57:23","modified_gmt":"2026-05-16T12:57:23","slug":"brnensti-vedci-nasli-bod-zlomu-v-bunce-moment-ktery-startuje-rakovinu","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/cz\/87634\/","title":{"rendered":"Brn\u011bn\u0161t\u00ed v\u011bdci na\u0161li bod zlomu v\u00a0bu\u0148ce: moment, kter\u00fd startuje rakovinu"},"content":{"rendered":"

Zjednodu\u0161en\u011b \u0159e\u010deno, bu\u0148ky v\u00a0lidsk\u00e9m t\u011ble neust\u00e1le vyhodnocuj\u00ed sign\u00e1ly ze sv\u00e9ho okol\u00ed a\u00a0podle nich se rozhoduj\u00ed, zda se za\u010dnou d\u011blit, r\u016fst nebo naopak z\u016fstanou v\u00a0klidu.<\/p>\n

Jedn\u00edm z\u00a0kl\u00ed\u010dov\u00fdch syst\u00e9m\u016f, kter\u00fd tuto komunikaci \u0159\u00edd\u00ed, je tzv. Wnt signaliza\u010dn\u00ed dr\u00e1ha. Je to mechanismus, kter\u00fd koordinuje miliardy bun\u011bk v\u00a0t\u011ble. Stoj\u00ed za t\u00edm, \u017ee se z\u00a0jedin\u00e9 bu\u0148ky vyvine cel\u00fd organismus, a\u00a0v dosp\u011blosti \u0159\u00edd\u00ed obnovu tk\u00e1n\u00ed. Dosud nebylo jasn\u00e9, jak p\u0159esn\u011b tento mechanismus funguje. <\/p>\n

Protein jako p\u0159ep\u00edna\u010d<\/p>\n

Nov\u00fd v\u00fdzkum nyn\u00ed popsal, \u017ee bu\u0148ka nereaguje na podn\u011bty plynule, ale sp\u00ed\u0161e v\u00a0re\u017eimu ano\u2013ne po p\u0159ekro\u010den\u00ed ur\u010dit\u00e9 rozhodovac\u00ed hranice. Tento princip m\u011bn\u00ed na\u0161e ch\u00e1p\u00e1n\u00ed vz\u00e1jemn\u00e9ho fungov\u00e1n\u00ed bun\u011bk a\u00a0umo\u017e\u0148uje l\u00e9pe porozum\u011bt situac\u00edm, kdy se bun\u011b\u010dn\u00e9 rozhodov\u00e1n\u00ed vymkne kontrole a\u00a0m\u016f\u017ee zp\u016fsobit rakovinn\u00e9 bujen\u00ed, uvedl prvn\u00ed autor studie<\/a> Miroslav Micka. <\/p>\n

<\/a><\/p>\n

Proces za\u010d\u00edn\u00e1 na povrchu bu\u0148ky, kde sign\u00e1l zachyt\u00ed receptor ukotven\u00fd v\u00a0tzv. bun\u011b\u010dn\u00e9 membr\u00e1n\u011b. Na n\u011bj se nav\u00e1\u017ee protein Dishevelled (DVL), kter\u00fd p\u0159en\u00e1\u0161\u00ed informaci d\u00e1le do bu\u0148ky. Aby DVL mohl pokra\u010dovat dovnit\u0159 bu\u0148ky, mus\u00ed se nejprve chemicky upravit\u00a0\u2013 na jeho povrchu se za\u010dnou hromadit drobn\u00e9 chemick\u00e9 skupiny, kter\u00e9 postupn\u011b zvy\u0161uj\u00ed jeho z\u00e1porn\u00fd n\u00e1boj. <\/p>\n

A pr\u00e1v\u011b tady p\u0159ich\u00e1z\u00ed moment, kter\u00fd rozhoduje. \u201eZjistili jsme, \u017ee protein DVL se chov\u00e1 jako p\u0159ep\u00edna\u010d\u00a0\u2013 svou strukturu zm\u011bn\u00ed, jakmile z\u00e1porn\u00fd n\u00e1boj na jeho povrchu p\u0159ekro\u010d\u00ed ur\u010ditou prahovou hodnotu. Teprve v\u00a0tu chv\u00edli p\u0159eskup\u00ed svou strukturu a\u00a0umo\u017en\u00ed dal\u0161\u00ed krok v\u00a0p\u0159enosu sign\u00e1lu,\u201c doplnil Micka. Bu\u0148ka tak dost\u00e1v\u00e1 jasn\u00fd pokyn, co m\u00e1 vlastn\u011b d\u011blat.<\/p>\n

D\u016fle\u017eit\u00fd je tedy onen bod zlomu, kdy\u017e je bu\u0148ce vysl\u00e1n sign\u00e1l. Dosud jej v\u011bda ch\u00e1pala jen \u010d\u00e1ste\u010dn\u011b. V\u011bd\u011blo se sice, kudy sign\u00e1l proch\u00e1z\u00ed, ale odborn\u00edci jej ch\u00e1pali p\u0159edev\u0161\u00edm jako plynul\u00fd regula\u010dn\u00ed syst\u00e9m. Nov\u00fd v\u00fdzkum v\u0161ak uk\u00e1zal, \u017ee jde sp\u00ed\u0161e o\u00a0proces zalo\u017een\u00fd na n\u00e1hl\u00e9 zm\u011bn\u011b po p\u0159ekro\u010den\u00ed ur\u010dit\u00e9ho prahu.<\/p>\n

Rozkl\u00ed\u010dov\u00e1n\u00ed podobn\u00fdch mechanism\u016f tak p\u0159ibli\u017euje medic\u00ednu \u00fa\u010dinn\u011bj\u0161\u00edm terapi\u00edm.<\/p>\n

Foto: Tripsianes Lab, CEITEC<\/p>\n

Sch\u00e9ma vysv\u011btluj\u00edc\u00ed nov\u00fd zp\u016fsob p\u0159enosu sign\u00e1lu Wnt<\/p>\n

<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Zjednodu\u0161en\u011b \u0159e\u010deno, bu\u0148ky v\u00a0lidsk\u00e9m t\u011ble neust\u00e1le vyhodnocuj\u00ed sign\u00e1ly ze sv\u00e9ho okol\u00ed a\u00a0podle nich se rozhoduj\u00ed, zda se za\u010dnou…\n","protected":false},"author":2,"featured_media":87635,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_share_on_mastodon":"0"},"categories":[7],"tags":[92,27188,22582,43,42,41,40,3684,16908,2811,77],"class_list":["post-87634","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cesko","tag-brno","tag-bunky","tag-ceitec","tag-ceska-republika","tag-cesko","tag-czech-republic","tag-czechia","tag-muni","tag-protein","tag-rakovina","tag-veda"],"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@cz\/116584372491249984","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/posts\/87634","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/comments?post=87634"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/posts\/87634\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/media\/87635"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/media?parent=87634"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/categories?post=87634"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/cz\/wp-json\/wp\/v2\/tags?post=87634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}