WASHINGTON (dpa-AFX) – A new study published in The Lancet looked at more than 58,000 people to compare 30 antidepressants with a placebo over eight weeks. <\/p>\n
At the end of the study, the researchers found clear differences in how these drugs affect blood flow, metabolism, weight, heart rate, blood pressure, and cholesterol.<\/p>\n
Some antidepressants, such as maprotiline and amitriptyline, were linked to weight gain of about 4 pounds on average, while others, like agomelatine, were tied to weight loss of about 5.5 pounds in over half of patients. <\/p>\n
Heart rate changes also varied, showing that nortriptyline raised it by about 14 beats per minute, while fluvoxamine lowered it by about 8.<\/p>\n
Notably, most drugs did not significantly affect kidney or liver function, electrolyte levels, or heart rhythm. <\/p>\n
‚It may be that one medication, which is pretty bad for one person, actually is pretty good for another one. I think that is the message, rather than naming and shaming certain drugs,‘ lead author Toby Pillinger said.<\/p>\n
The researchers emphasized that people should not stop taking antidepressants, as they remain effective, but doctors should aim to better match treatments to each person’s health needs.<\/p>\n
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