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<\/a> Image source: The Motley Fool. <\/p>\nMissed Nvidia in 2009? This Rare Signal Is Flashing Again.\u00a0In 2009, a “Double Down” signal flashed for a little-known chipmaker called Nvidia.\u00a0For the first time in years, that same “Total Conviction” signal is flashing for a company 1\/100th the size of Nvidia.\u00a0Continue \u00bb<\/a> <\/p>\n Comparing their GLP-1 businesses <\/p>\n Eli Lilly’s tirzepatide, marketed as Mounjaro for diabetes and Zepbound for weight management, is a direct competitor to Novo Nordisk’s semaglutide, known under the brand names Ozempic and Wegovy. Tirzepatide has a different mechanism of action. It mimics the action of two gut hormones: GLP-1<\/a> and GIP, versus just one for semaglutide. This dual-pathway approach is one reason tirzepatide has proven more effective for chronic weight management. In a head-to-head study, it led to an average weight loss of 20.2% versus semaglutide’s 13.7% after 72 weeks. Tirzepatide is posting much better sales as a result. <\/p>\n Focusing on the weight-loss segment, note that in the second quarter, Zepbound’s revenue was $4.9 billion, up 46% year over year. Wegovy’s sales came in at 19.4 billion Danish kroner — or about $3 billion — up only 1% compared to the year-ago period. Also, Zepbound outperformed Novo Nordisk’s next-gen weight-management drug, CagriSema, in a head-to-head study conducted by the Denmark-based pharmaceutical leader<\/a>. <\/p>\n Even when we look at their pipelines, Eli Lilly comes out on top. The company’s retatrutide is an up-and-coming weight loss medicine that seems even more effective than Zepbound. True, Novo Nordisk arguably has the edge in the oral weight-loss market, with the Wegovy pill capturing a larger market share than Eli Lilly’s Foundayo. Still, Eli Lilly is winning the GLP-1 battle overall and should continue to do so. <\/p>\n Beyond diabetes and weight loss <\/p>\n Eli Lilly’s portfolio also features several promising drugs beyond its core therapeutic areas, including billion-dollar products such as Verzenio, a cancer medicine, and Taltz, an immunosuppressant. Several of its newer drugs could also eventually generate well above $1 billion in annual sales at their peak. The list includes Kisunla in Alzheimer’s disease and Jaypirca in oncology. Eli Lilly has also significantly expanded its pipeline in recent years through acquisitions. Meanwhile, Novo Nordisk’s potential outside its core area looks far more limited — and its pipeline isn’t nearly as large as Eli Lilly’s. So, Eli Lilly is also a better company in this category. <\/p>\n A clear winner <\/p>\n Some may point out that Novo Nordisk is trading at 13.8x forward earnings, compared to an average of 18.5x for healthcare stocks, and a much higher 32.7x for Eli Lilly. However, Eli Lilly is growing its revenue and earnings much faster and beats Novo Nordisk on most other meaningful metrics. Eli Lilly is clearly the better buy between these two GLP-1 leaders. <\/p>\n Should you buy stock in Eli Lilly right now? <\/p>\n Before you buy stock in\u00a0Eli Lilly, consider this: <\/p>\n The Motley Fool\u00a0Stock Advisor\u00a0analyst team just identified what they believe are the\u00a010 best stocks<\/a>\u00a0for investors to buy now\u2026 and\u00a0Eli Lilly\u00a0wasn’t one of them.\u00a0The 10 stocks that made the cut are built for long-term growth and could produce monster returns in the coming years. <\/p>\n Consider when\u00a0Netflix\u00a0made this list on December 17, 2004… if you invested $1,000 at the time of our recommendation,\u00a0you’d have $411,427!*\u00a0Or\u00a0when\u00a0Nvidia\u00a0made this list on April 15, 2005… if you invested $1,000 at the time of our recommendation,\u00a0you’d have $1,335,252!* <\/p>\n That performance is why people listen. With a track record of\u00a0beating the S&P 500 by 4x,\u00a0Stock Advisor\u00a0offers a distinct advantage. Don’t miss the latest top 10 list, available with\u00a0Stock Advisor, and join an investing community built for the long haul. <\/p>\n See the 10 stocks \u00bb<\/a> <\/p>\n *Stock Advisor returns as of August 11, 2026. <\/p>\n Prosper Junior Bakiny<\/a> has positions in Eli Lilly and Novo Nordisk. The Motley Fool has positions in and recommends Eli Lilly and Novo Nordisk. The Motley Fool has a disclosure policy<\/a>. <\/p>\n