Will AI create the world’s first trillionaire? Our team just released a report on the one little-known company, called an “Indispensable Monopoly” providing the critical technology Nvidia and Intel both need. Continue \u00bb<\/a><\/p>\n But this is the first of a one-two punch from Eli Lilly that could cement the company atop the weight-loss drug market for the foreseeable future.<\/p>\n A dollar sign composed of several different colors of pills and capsules.<\/p>\n Image source: Getty Images.<\/p>\n The second GLP-1 pill for weight loss comes with an important first<\/p>\n Early demand for Novo Nordisk’s oral formulation of Wegovy suggests a pent-up appetite for anti-obesity drugs that you don’t need to self-inject. Eli Lilly is second to market with orforglipron, but there’s reason to believe it will ultimately outsell the Wegovy pill.<\/p>\n Most notably, orforglipron has no food or water restrictions. In contrast, patients must take the Wegovy pill on an empty stomach, avoiding food or other medications for 30 minutes; otherwise, it may not work, because stomach enzymes can break it down.<\/p>\n That’s quite an inconvenience, as many people are used to taking their pills when they wake up and then going about their day. Novo Nordisk’s Rybelsus, a GLP-1 pill for diabetes, has similar restrictions and hasn’t achieved anywhere near the sales that Ozempic has.<\/p>\n The real knockout blow could be Eli Lilly’s next move<\/p>\n Semaglutide, the key drug in Ozempic and Wegovy, is a peptide. It breaks down in the stomach, which is why subcutaneous versions achieve far higher efficacy.<\/p>\n Eli Lilly’s biggest blockbuster yet could be retatrutide, a subcutaneous triple-hormone receptor agonist, the first of its kind. Retatrutide is still in phase 3 trials, but the readout data thus far indicate it could be steep competition. In its first phase 3 trial, patients taking the 12mg dose lost an average of 28.7% of body weight over 68 weeks.<\/p>\n Novo Nordisk’s next-generation subcutaneous drug, cagrilintide-semaglutide (CagriSema), achieved an average 23% reduction over 84 weeks in a recent trial. That failed to meet its primary endpoint of noninferiority compared to Lilly’s tirzepatide, the existing drug sold as Mounjaro and Zepbound. In other words, retatrutide is setting new performance milestones while CagriSema failed to outperform the old benchmark.<\/p>\n The problem facing Novo Nordisk is that its next potential winner<\/a> is still quite far away; drug development takes years. That means Eli Lilly could be running circles around Novo Nordisk with orforglipron and retatrutide for the foreseeable future.<\/p>\n Should you buy stock in Eli Lilly right now?<\/p>\n Before you buy stock in Eli Lilly, consider this:<\/p>\n The Motley Fool Stock Advisor analyst team just identified what they believe are the 10 best stocks<\/a> for investors to buy now\u2026 and Eli Lilly wasn\u2019t one of them. The 10 stocks that made the cut could produce monster returns in the coming years.<\/p>\n Consider when Netflix made this list on December 17, 2004… if you invested $1,000 at the time of our recommendation, you\u2019d have $532,066!* Or when Nvidia made this list on April 15, 2005… if you invested $1,000 at the time of our recommendation, you\u2019d have $1,087,496!*<\/p>\n Now, it\u2019s worth noting Stock Advisor\u2019s total average return is 926% \u2014 a market-crushing outperformance compared to 185% for the S&P 500. Don’t miss the latest top 10 list, available with Stock Advisor, and join an investing community built by individual investors for individual investors.<\/p>\n See the 10 stocks \u00bb<\/a><\/p>\n *Stock Advisor returns as of April 4, 2026. <\/p>\n Justin Pope<\/a> has no position in any of the stocks mentioned. The Motley Fool recommends Novo Nordisk. The Motley Fool has a disclosure policy<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"Key Points Foundayo (orforglipron) has a serious advantage over Novo Nordisk’s Wegovy pill. 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