{"id":123879,"date":"2025-05-24T06:40:08","date_gmt":"2025-05-24T06:40:08","guid":{"rendered":"https:\/\/www.europesays.com\/fr\/123879\/"},"modified":"2025-05-24T06:40:08","modified_gmt":"2025-05-24T06:40:08","slug":"comment-un-donneur-de-sperme-a-transmis-un-gene-predisposant-au-cancer-a-des-dizaines-denfants-en-europe","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/fr\/123879\/","title":{"rendered":"Comment un donneur de sperme a transmis un g\u00e8ne pr\u00e9disposant au cancer \u00e0 des dizaines d\u2019enfants en Europe"},"content":{"rendered":"

L\u2019homme, qui a r\u00e9alis\u00e9 son don dans une banque de sperme priv\u00e9e au Danemark, \u00e9tait porteur d\u2019un variant favorisant la survenue de cancers pr\u00e9coces. Il est \u00e0 l\u2019origine d\u2019au moins 67 naissances, dont au moins 23 enfants concern\u00e9s par l\u2019anomalie g\u00e9n\u00e9tique.<\/p>\n

C\u2019est un courrier inattendu et tr\u00e8s inqui\u00e9tant qu\u2019une famille fran\u00e7aise a re\u00e7u au cours de l\u2019ann\u00e9e 2023\u00a0: une\u00a0banque de sperme<\/a>\u00a0priv\u00e9e danoise \u00e0 laquelle ils avaient eu recours pour concevoir leur enfant avait constat\u00e9 a posteriori que les gam\u00e8tes du donneur \u00e9taient porteurs d\u2019un \u00ab\u00a0variant de signification incertaine sur le g\u00e8ne TP53\u00a0\u00bb. Le courrier pr\u00e9cisait que le donneur lui-m\u00eame \u00e9tait en bonne sant\u00e9, mais que si l\u2019enfant \u00e9tait porteur de ce m\u00eame variant, il pouvait \u00eatre atteint du\u00a0syndrome de Li-Fraumeni<\/a>. Un syndrome tr\u00e8s rare (environ une naissance sur 5000), qui\u00a0favorise la survenue de cancers<\/a>\u00a0pr\u00e9coces.<\/p>\n

Sp\u00e9cialiste des pr\u00e9dispositions h\u00e9r\u00e9ditaires au cancer, et notamment du syndrome de Li-Fraumeni, Edwige Kasper, docteur en pharmacie et biologiste en oncog\u00e9n\u00e9tique au CHU de Rouen, est sollicit\u00e9e fin 2023 par le m\u00e9decin qui a re\u00e7u la famille. Le g\u00e8ne TP53 pilote la production d\u2019une prot\u00e9ine charg\u00e9e d\u2019emp\u00eacher les cellules de se diviser de fa\u00e7on incontr\u00f4l\u00e9e, et on sait que certaines\u2026<\/p>\n

\n Cet article est r\u00e9serv\u00e9 aux abonn\u00e9s. Il vous reste 88% \u00e0 d\u00e9couvrir.\n <\/p>\n

\"Le<\/p>\n

Vente Flash<\/p>\n

4,99\u20ac par mois pendant 12 mois. Sans engagement.<\/p>\n

\n D\u00e9j\u00e0 abonn\u00e9\u00a0?
\n Connectez-vous
\n <\/a>\n <\/p>\n","protected":false},"excerpt":{"rendered":"L\u2019homme, qui a r\u00e9alis\u00e9 son don dans une banque de sperme priv\u00e9e au Danemark, \u00e9tait porteur d\u2019un variant…\n","protected":false},"author":2,"featured_media":123880,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[442,228,440,441,436,1011,27,72,226,439,229,71,435,437,227,438],"class_list":{"0":"post-123879","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-sante","8":"tag-administration-de-la-sante","9":"tag-diagnostic","10":"tag-droit-a-la-sante","11":"tag-education-sanitaire-education-sanitaire-individuelle-et-collective","12":"tag-environnement","13":"tag-fr","14":"tag-france","15":"tag-health","16":"tag-maladie","17":"tag-niveau-de-vie","18":"tag-pathologie","19":"tag-sante","20":"tag-sante-de-la-population","21":"tag-services-medicaux","22":"tag-traitement","23":"tag-traitement-preventif"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@fr\/114561445054690895","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/posts\/123879","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/comments?post=123879"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/posts\/123879\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/media\/123880"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/media?parent=123879"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/categories?post=123879"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/tags?post=123879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}