{"id":270897,"date":"2025-07-24T17:02:16","date_gmt":"2025-07-24T17:02:16","guid":{"rendered":"https:\/\/www.europesays.com\/fr\/270897\/"},"modified":"2025-07-24T17:02:16","modified_gmt":"2025-07-24T17:02:16","slug":"trop-de-femmes-enceintes-prennent-encore-des-antiepileptiques-a-risque","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/fr\/270897\/","title":{"rendered":"Trop de femmes enceintes prennent encore des anti\u00e9pileptiques \u00e0 risque"},"content":{"rendered":"

L\u2019encadrement strict de l\u2019usage de l\u2019acide valpro\u00efque pendant la grossesse n\u2019a pas \u00e9t\u00e9 accompagn\u00e9 de recommandations de substitution.
\n \u041e\u043b\u044c\u0433\u0430 \u0422\u0435\u0440\u043d\u0430\u0432\u0441\u043a\u0430\u044f – stock.adobe.com<\/p>\n

Une \u00e9tude fran\u00e7aise pointe la baisse des prescriptions de valproate, la mol\u00e9cule active de la D\u00e9pakine, mais alerte sur une hausse de l\u2019utilisation d\u2019autres m\u00e9dicaments au profil de s\u00e9curit\u00e9 incertain.<\/p>\n

C\u2019est une bonne nouvelle, qui cache une tendance inqui\u00e9tante. En France, l\u2019exposition des femmes enceintes \u00e0 l\u2019acide valpro\u00efque (mol\u00e9cule active de la D\u00e9pakine) et \u00e0 son d\u00e9riv\u00e9, le valpromide, a fortement recul\u00e9 entre 2013 et 2021. Ces deux\u00a0anti\u00e9pileptiques<\/a>\u00a0sont connus pour leurs effets d\u00e9l\u00e9t\u00e8res sur le d\u00e9veloppement du f\u0153tus, avec des risques av\u00e9r\u00e9s de malformations cong\u00e9nitales et de\u00a0troubles neurod\u00e9veloppementaux<\/a>. Des ann\u00e9es de mobilisation ont permis\u00a0un encadrement plus strict des prescriptions<\/a>.<\/p>\n

Mais dans le m\u00eame temps, la prescription d\u2019autres anti\u00e9pileptiques,\u00a0au profil de s\u00e9curit\u00e9 pendant la grossesse encore mal \u00e9tabli<\/a>, a fortement augment\u00e9. Et pas uniquement chez les femmes atteintes d\u2019\u00e9pilepsie. Pr\u00e9gabaline, gabapentine, mol\u00e9cules de nouvelle g\u00e9n\u00e9ration… L\u2019exposition pr\u00e9natale \u00e0 ces traitements progresse, parfois de mani\u00e8re spectaculaire.<\/p>\n

Pr\u00e8s de 56\u00a0000 grossesses expos\u00e9es<\/p>\n

C\u2019est le constat d\u2019une \u00e9tude fran\u00e7aise d\u2019Epi-phare (groupement d\u2019int\u00e9r\u00eat scientifique constitu\u00e9 par l\u2019Agence nationale de s\u00e9curit\u00e9 du m\u00e9dicament\u2026<\/p>\n

\n Cet article est r\u00e9serv\u00e9 aux abonn\u00e9s. Il vous reste 82% \u00e0 d\u00e9couvrir.\n <\/p>\n

\"Le<\/p>\n

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\n <\/a>\n <\/p>\n","protected":false},"excerpt":{"rendered":"L\u2019encadrement strict de l\u2019usage de l\u2019acide valpro\u00efque pendant la grossesse n\u2019a pas \u00e9t\u00e9 accompagn\u00e9 de recommandations de substitution.…\n","protected":false},"author":2,"featured_media":270898,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[41027,41029,41026,1011,27,72,41028,71],"class_list":{"0":"post-270897","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-sante","8":"tag-antiepileptiques","9":"tag-depakine","10":"tag-epilepsie","11":"tag-fr","12":"tag-france","13":"tag-health","14":"tag-maladie-et-grossesse","15":"tag-sante"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@fr\/114909291751158453","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/posts\/270897","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/comments?post=270897"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/posts\/270897\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/media\/270898"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/media?parent=270897"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/categories?post=270897"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/fr\/wp-json\/wp\/v2\/tags?post=270897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}