Abou Elella R, Najm HK, Balkhy H, Bullard L, Kabbani MS. Impact of bloodstream infection on the outcome of children undergoing cardiac surgery. Pediatr Cardiol. 2010;31(4):483–9.
Ben Jaballah N, Bouziri A, Mnif K, Hamdi A, Khaldi A, Kchaou W. Epidemiology of hospital-acquired bloodstream infections in a Tunisian pediatric intensive care unit: a 2-year prospective study. Am J Infect Control. 2007;35(9):613–8.
Grisaru-Soen G, Sweed Y, Lerner-Geva L, Hirsh-Yechezkel G, Boyko V, Vardi A, et al. Nosocomial bloodstream infections in a pediatric intensive care unit: 3-year survey. Med Sci Monit. 2007;13(6):Cr251–7.
Dabaja-Younis H, Alaiyan M, Shalabi RD, Ben-Ari J, Alon T, Hadash A, et al. Six-Year surveillance of acquired bloodstream infection in a pediatric intensive care unit in Israel. Indian Pediatr. 2023;60(1):41–4.
Ruvinsky S, Voto C, Roel M, Deschutter V, Ferraro D, Aquino N, et al. Carbapenem-resistant Enterobacteriaceae bloodstream infections: A case-control study from a pediatric referral hospital in Argentina. Front Public Health. 2022;10:983174.
Pong S, Fowler RA, Murthy S, Pernica JM, Gilfoyle E, Fontela P, et al. Antimicrobial treatment duration for uncomplicated bloodstream infections in critically ill children: a multicentre observational study. BMC Pediatr. 2022;22(1):179.
Alwazzeh MJ, Alnimr A, Al Nassri SA, Alwarthan SM, Alhajri M, AlShehail BM, et al. Microbiological trends and mortality risk factors of central line-associated bloodstream infections in an academic medical center 2015–2020. Antimicrob Resist Infect Control. 2023;12(1):128.
Bangeas A, Protonotariou E, Hatzipantelis E, Palabougiouki M, Ioannidou M, Skoura L, et al. Clinical characteristics and risk factors for bloodstream infections in children with cancer: A report from a pediatric hematology oncology unit. Cardiovasc Hematol Agents Med Chem. 2023;21(3):193–201.
Wang H, Liu J, Huang Z, Tao X, Li J, Hu Y, et al. Clinical characteristics and risk factors for shock and death from E. coli bacteremia in pediatric hematological patients. J Infect Dev Ctries. 2019;13(5):365–73.
Aksoy BA, Kara M, Sütçü M, Özbek A, Ersoy GZ, Öner ÖB, et al. Epidemiologic and microbiologic evaluation of catheter-line bloodstream infection in a pediatric hematopoietic stem cell transplant center. Am J Infect Control. 2024;52(1):81–6.
Ruvinsky S, Aquino N, Lenz AM, Magliola R, Herrera C, Schaigorodsky L, et al. Effectiveness of a program for the reduction of central venous catheter-related bacteremias in a pediatric cardiovascular unit. Arch Argent Pediatr. 2022;120(5):304–9.
Posfay-Barbe KM, Zerr DM, Pittet D. Infection control in paediatrics. Lancet Infect Dis. 2008;8(1):19–31.
Wattal C, Oberoi J. Infections in pediatric intensive care units (PICU). Indian J Pediatr. 2012;79(5):647–9.
Gumus DD, Demir OO, Aykac K, Hazirolan G, Avci H, Ceyhan M, et al. Gram-negative bacteremia, the risk factors, and outcome in children. Diagn Microbiol Infect Dis. 2024;109(3):116324.
Carlesse F, Russo C, Seber A, Castagnola E. Epidemiology of bloodstream infections and the impact of antimicrobial resistance in pediatric hematopoietic cell transplant. Transpl Infect Dis. 2024;26(1):e14228.
Gebremicael MN, Nuttall JJC, Tootla HD, Khumalo A, Tooke L, Salie S, et al. Candida bloodstream infection among children hospitalised in three public-sector hospitals in the metro West region of cape Town, South Africa. BMC Infect Dis. 2023;23(1):67.
Droz N, Hsia Y, Ellis S, Dramowski A, Sharland M, Basmaci R. Bacterial pathogens and resistance causing community acquired paediatric bloodstream infections in low- and middle-income countries: a systematic review and meta-analysis. Antimicrob Resist Infect Control. 2019;8:207.
Zeng X, Yu G, Lu Y, Tan L, Wu X, Shi S, et al. PIC, a paediatric-specific intensive care database. Sci Data. 2020;7(1):14.
Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18(3):268–81.
Gibbs AAM, Laupland KB, Edwards F, Ling W, Channon-Wells S, Harley D et al. Trends in enterobacterales bloodstream infections in children. Pediatrics. 2024;154(4):e2023063532.
Wen SCH, Harris PNA, Forde B, Permana B, Chatfield MD, Lau CL, et al. Characterization of Gram-negative bloodstream infections in hospitalized Australian children and their clinical outcomes. Clin Infect Dis. 2024;79(3):734–43.
Gando S. Microvascular thrombosis and multiple organ dysfunction syndrome. Crit Care Med. 2010;38(2 Suppl):S35–42.
Perrin J, Charron C, François JH, Cramer-Bordé E, Lévy B, Borgel D, et al. Coagulation phenotypes in septic shock as evaluated by calibrated automated thrombography. Shock. 2015;43(1):74–9.
Thiery-Antier N, Binquet C, Vinault S, Meziani F, Boisramé-Helms J, Quenot JP. Is thrombocytopenia an early prognostic marker in septic shock? Crit Care Med. 2016;44(4):764–72.
Levi M, van der Poll T. Coagulation and sepsis. Thromb Res. 2017;149:38–44.
Kinasewitz GT, Yan SB, Basson B, Comp P, Russell JA, Cariou A, et al. Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]. Crit Care. 2004;8(2):R82–90.
MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M. Early coagulopathy predicts mortality in trauma. J Trauma. 2003;55(1):39–44.
Parlato M, Philippart F, Rouquette A, Moucadel V, Puchois V, Blein S, et al. Circulating biomarkers May be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study. Intensive Care Med. 2018;44(7):1061–70.
Oliveira CF, Botoni FA, Oliveira CR, Silva CB, Pereira HA, Serufo JC, et al. Procalcitonin versus C-reactive protein for guiding antibiotic therapy in sepsis: a randomized trial. Crit Care Med. 2013;41(10):2336–43.
Li W, Luo S, Zhu Y, Wen Y, Shu M, Wan C. C-reactive protein concentrations can help to determine which febrile infants under three months should receive blood cultures during influenza seasons. Acta Paediatr. 2017;106(12):2017–24.
Chiu IM, Huang YH, Su CM, Kung CT, Li CJ, Chen CH, et al. C-Reactive protein concentration can help to identify bacteremia in children visiting the emergency department: A single medical center experience. Pediatr Emerg Care. 2020;36(6):291–5.
Akirov A, Masri-Iraqi H, Atamna A, Shimon I. Low albumin levels are associated with mortality risk in hospitalized patients. Am J Med. 2017;130(12):1465. e11-.e19.
Zhang Y, Shi Q, Zhong G, Lei X, Lin J, Fu Z, et al. Biomarker-based score for predicting in-hospital mortality of children admitted to the intensive care unit. J Investig Med. 2021;69(8):1458–63.
Ari HF, Turanli EE, Yavuz S, Guvenc K, Avci A, Keskin A et al. Association between serum albumin levels at admission and clinical outcomes in pediatric intensive care units: a multi-center study. BMC Pediatr. 2024;24(1):844.
Shao H, Zhang X, Li Y, Gao Y, Wang Y, Shao X, et al. Epidemiology and drug resistance analysis of bloodstream infections in an intensive care unit from a children’s medical center in Eastern China for six consecutive years. Int Microbiol. 2024;27(5):1345–55.
Santella B, Folliero V, Pirofalo GM, Serretiello E, Zannella C, Moccia G, et al. Sepsis—A retrospective cohort study of bloodstream infections. Antibiotics. 2020;9(12):851.
Wang C, Hao W, Yu R, Wang X, Zhang J, Wang B. Analysis of pathogen distribution and its antimicrobial resistance in bloodstream infections in hospitalized children in East China, 2015–2018. J Trop Pediatr. 2020;67(1) :fmaa077.
Dambroso-Altafini D, Menegucci TC, Costa BB, Moreira RRB, Nishiyama SAB, Mazucheli J, et al. Routine laboratory biomarkers used to predict Gram-positive or Gram-negative bacteria involved in bloodstream infections. Sci Rep. 2022;12(1):15466.
Amanati A, Sajedianfard S, Khajeh S, Ghasempour S, Mehrangiz S, Nematolahi S, et al. Bloodstream infections in adult patients with malignancy, epidemiology, microbiology, and risk factors associated with mortality and multi-drug resistance. BMC Infect Dis. 2021;21(1):636.
Zain OM, Elsayed MY, Abdelkhalig SM, Abdelaziz M, Ibrahim SY, Bashir T, et al. Bloodstream infection in cancer patients; susceptibility profiles of the isolated pathogens, at Khartoum oncology Hospital, Sudan. Afr Health Sci. 2022;22(4):70–6.
Dou JY, Zhou YP, Cui Y, Sun T, Shi JY, Xiong X, et al. [Pathogenic characteristics and influence factors of bloodstream infection-induced severe sepsis in pediatric intensive care unit]. Zhonghua Yi Xue Za Zhi. 2024;104(3):198–204.
Lee Y, Puumala E, Robbins N, Cowen LE. Antifungal drug resistance: molecular mechanisms in Candida albicans and beyond. Chem Rev. 2021;121(6):3390–411.
Lakshmi KS, Jayashree M, Singhi S, Ray P. Study of nosocomial primary bloodstream infections in a pediatric intensive care unit. J Trop Pediatr. 2007;53(2):87–92.
Arı HF, Arı M. The evaluation of nosocomial candidemia in pediatric intensive care: A Single-center study. Turkish J Intensive Care. 2023;21(4):239–47.
Kiani D, Quinn EL, Burch KH, Madhavan T, Saravolatz LD, Neblett TR. The increasing importance of polymicrobial bacteremia. JAMA. 1979;242(10):1044–7.
Rello J, Quintana E, Mirelis B, Gurguí M, Net A, Prats G. Polymicrobial bacteremia in critically ill patients. Intensive Care Med. 1993;19(1):22–5.
Lin JN, Lai CH, Chen YH, Chang LL, Lu PL, Tsai SS, et al. Characteristics and outcomes of polymicrobial bloodstream infections in the emergency department: A matched case-control study. Acad Emerg Med. 2010;17(10):1072–9.
Diekema DJ, Hsueh PR, Mendes RE, Pfaller MA, Rolston KV, Sader HS et al. The microbiology of bloodstream infection: 20-Year trends from the SENTRY antimicrobial surveillance program. Antimicrob Agents Chemother. 2019;63(7):e00355-19.
Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev. 2007;20(1):133–63.
Alkan Ozdemir S, Arun Ozer E, Ilhan O, Sutcuoglu S. Can neutrophil to lymphocyte ratio predict late-onset sepsis in preterm infants? J Clin Lab Anal. 2018;32(4):e22338.
Agrawal S, Sachdev A, Gupta D, Chugh K. Platelet counts and outcome in the pediatric intensive care unit. Indian J Crit Care Med. 2008;12(3):102–8.
Benediktsson S, Frigyesi A, Kander T. Routine coagulation tests on ICU admission are associated with mortality in sepsis: an observational study. Acta Anaesthesiol Scand. 2017;61(7):790–6.
Xu Z, Cheng B, Fu S, Liu X, Xie G, Li Z, et al. Coagulative biomarkers on admission to the ICU predict acute kidney injury and mortality in patients with septic shock caused by intra-abdominal infection. Infect Drug Resist. 2019;12:2755–64.
Innocenti F, Meo F, Giacomelli I, Tozzi C, Ralli ML, Donnini C, et al. Prognostic value of serial lactate levels in septic patients with and without shock. Intern Emerg Med. 2019;14(8):1321–30.
Yu G, Yoo SJ, Lee SH, Kim JS, Jung S, Kim YJ, et al. Utility of the early lactate area score as a prognostic marker for septic shock patients in the emergency department. Acute Crit Care. 2019;34(2):126–32.
Liu Z, Meng Z, Li Y, Zhao J, Wu S, Gou S, et al. Prognostic accuracy of the serum lactate level, the SOFA score and the qSOFA score for mortality among adults with sepsis. Scand J Trauma Resusc Emerg Med. 2019;27(1):51.
Arı HF, Keskin A, Arı M, Aci R. Importance of Lactate/Albumin ratio in pediatric nosocomial infection and mortality at different times. Future Microbiol. 2023;19(1):51–9.