Integrating physicochemical laws into future AI models for better drug design
Proteins play a key role not only in the body, but also in medicine: they either serve as…
Evolutionary mutation in cGAS enhances naked mole-rat DNA repair
The secret to the naked mole-rats’ extraordinarily long life may lie in subtle changes to just four amino…
New computer-driven method helps understand how membrane proteins work at the atomic level
Cellular membrane proteins play many important roles throughout the body, including transporting substances in and out of the…
New tool enables and enhances protein investigations
A new tool greatly improves scientists’ ability to identify and study proteins that regulate gene activity in cells,…
Scientists uncover how amino acids stabilize proteins in solution
For decades, amino acids have been added to medical formulations like insulin as stabilizers: these small molecules keep…
New mouse models reveal mechanisms of RP59 retinal degeneration
Retinitis pigmentosa retinal degeneration is caused by a family of hereditary mutations in nearly 100 genes that slowly…
BindCraft reimagines protein binder discovery through structural prediction
Physical interactions between proteins influence anything from cell signaling and growth to immune responses, so the ability to…
Amino acid metabolism shapes the tumor immune microenvironment and therapy response
The tumor microenvironment is not just a site of cancer growth—it is a high-stakes metabolic contest where tumor…