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Browsing Tag

Biomedicine

71 posts
GGenetics
Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function
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Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function

  • October 22, 2025
Institute of Medical Genetics, University of Zurich, Zurich, Switzerland Reza Asadollahi, Paranchai Boonsawat, Dennis Kraemer & Anita Rauch Faculty of Engineering and…
HHealth
Cardiometabolic multimorbidity, social activity, and joint trajectories of physical disability, depressive symptom, and cognitive function in mid-to-late life: a multicohort study | BMC Medicine
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Cardiometabolic multimorbidity, social activity, and joint trajectories of physical disability, depressive symptom, and cognitive function in mid-to-late life: a multicohort study | BMC Medicine

  • October 22, 2025
Flood D, Guwatudde D, Damasceno A, Manne-Goehler J, Davies JI, Project GHP. Maximising use of population data on…
GGenetics
Modeling heterogeneity in single-cell perturbation states enhances detection of response eQTLs
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Modeling heterogeneity in single-cell perturbation states enhances detection of response eQTLs

  • October 21, 2025
Cohorts We used published data (GEO accession no. GSE162632) to study the effect of 12 h of ex vivo…
GGenetics
Genotyping sequence-resolved copy number variation using pangenomes reveals paralog-specific global diversity and expression divergence of duplicated genes
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Genotyping sequence-resolved copy number variation using pangenomes reveals paralog-specific global diversity and expression divergence of duplicated genes

  • October 20, 2025
Constructing the pangenome-derived allele databaseSearch and extraction of initial genes of interest from pangenome assemblies Our pangenome cohort…
GGenetics
Association of genetic variants in m1A modification core genes and neuroblastoma risk | BMC Cancer
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Association of genetic variants in m1A modification core genes and neuroblastoma risk | BMC Cancer

  • October 18, 2025
Park JR, Kreissman SG, London WB, Naranjo A, Cohn SL, Hogarty MD, et al. Effect of tandem autologous…
GGenetics
Redefining cellular reprogramming with advanced genomic technologies
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Redefining cellular reprogramming with advanced genomic technologies

  • October 18, 2025
Briggs, R. & King, T. J. Transplantation of living nuclei from blastula cells into enucleated Frogs’ eggs. Proc.…
HHealth
Curcumin in prostate cancer: a systematic review of molecular mechanisms and nanoformulated therapeutic strategies | BMC Cancer
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Curcumin in prostate cancer: a systematic review of molecular mechanisms and nanoformulated therapeutic strategies | BMC Cancer

  • October 18, 2025
Curcumin, a dietary polyphenol derived from Curcuma longa, has been extensively studied for its pleiotropic biological activities, particularly…
GGenetics
Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers
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Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers

  • October 18, 2025
Genetic ancestry is a quantitative measure of inherited genetic variation and correlates with human migration patterns1. It contributes…
GGenetics
Characterization of induced cohesin loop extrusion trajectories in living cells
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Characterization of induced cohesin loop extrusion trajectories in living cells

  • October 17, 2025
Experiments performed in this study did not require ethics board approval. Cell culture HAP1 cells were cultured in…
HHealthcare
When helpfulness backfires: LLMs and the risk of false medical information due to sycophantic behavior
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When helpfulness backfires: LLMs and the risk of false medical information due to sycophantic behavior

  • October 17, 2025
To evaluate language models across varying levels of drug familiarity, we used the RABBITS30 dataset, which includes 550…
HHealth
Bioluminescent monitoring of a co-culture model of pathogen growth to identify a novel probiotic bacterium | BMC Research Notes
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Bioluminescent monitoring of a co-culture model of pathogen growth to identify a novel probiotic bacterium | BMC Research Notes

  • October 15, 2025
Lactobacillus delbrueckii inhibits the growth of MRSA We first examined the effect of L. delbrueckii on the growth…
HHealth
BioClock—optimizing Bright Light Therapy for adults with depression: a study protocol for a multicenter randomized clinical trial on treatment strategies, response predictors, and chronobiological and neurobiological mechanisms | Trials
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BioClock—optimizing Bright Light Therapy for adults with depression: a study protocol for a multicenter randomized clinical trial on treatment strategies, response predictors, and chronobiological and neurobiological mechanisms | Trials

  • October 14, 2025
Statistical methods for primary and secondary outcomes {20a} This analysis plan provides the initial framework for examining primary…
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