A comparison of 27 Arabidopsis thaliana genomes and the path toward an unbiased characterization of genetic polymorphism
DNA extraction and sequencing For long-read sequencing, we began with 3-week-old plants grown in soil that had been…
Peer perceptions of clinicians using generative AI in medical decision-making
A total of 276 clinicians participated in the study, including 178 physicians, 28 fellows/residents, 60 advanced practice providers…
Leveraging large language models for the deidentification and temporal normalization of sensitive health information in electronic health records
The OpenDeID v2 corpus To evaluate the performance of various machine learning methods and hybrid approaches that combine…
Implementing routine sexual and reproductive health screening into an Australian child and youth mental health service: study protocol for a cluster randomised controlled trial | Trials
Explanation for the choice of comparators {6b} The comparator for the current study is sites where the educational…
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy
Cancer is a genetic disease stemming from a combination of inherited and acquired mutations. Much of our understanding…
Methods and applications of in vivo CRISPR screening
Auton, A. et al. A global reference for human genetic variation. Nature 526, 68–74 (2015). PubMed Google Scholar …
Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs
Ethics We received approval to access and analyze deidentified genetic and phenotypic data from the two cohorts from…
Large-scale genome-wide analyses of stuttering
Yairi, E. & Ambrose, N. Epidemiology of stuttering: 21st century advances. J. Fluen. Disord. 38, 66–87 (2013). Google…
CRISPR-GPT for agentic automation of gene-editing experiments
Building AI co-pilot harnessing LLM’s reasoning ability CRISPR-GPT supports four major gene-editing modalities and 22 gene-editing experiment tasks…
Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas
GBD Chronic Kidney Disease Collaboration Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis…
Tracing the evolution of sequencing into the era of genomic medicine
Sanger, F., Nicklen, S. & Coulson, A. R. DNA sequencing with chain-terminating inhibitors. Proc. Natl Acad. Sci. USA…