Robust and accurate Bayesian inference of genome-wide genealogies for hundreds of genomes
An overview of the SINGER algorithm SINGER takes in phased WGS data and samples ARGs iteratively by adding…
Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer
de Magalhaes, J. P. How ageing processes influence cancer. Nat. Rev. Cancer 13, 357–365 (2013). Article PubMed Google…
Feasibility and clinical utility of expanded genomic newborn screening in the Early Check program
Enrollment rates Between 28 September 2023 and 10 June 2024 (~8.5 months), a total of 2,125 newborns were enrolled.…
PEPITEM shows promise in treating osteoporosis by enhancing bone health
Researchers from the University of Birmingham, U.K., have identified bioactive peptide sequences in PEPITEM molecule, and demonstrated the…
Practice of data sharing plans in clinical trial registrations and concordance between registered and published data sharing plans: a cross-sectional study | BMC Medicine
We reported this study according to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guideline [14].…
Pregnancy complications as a marker of future cardiovascular disease risk | BMC Medicine
The study by Wambua et al., Development and validation of a postpartum cardiovascular disease risk prediction model in…
Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression
James, S. L. et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354…
Development and validation of a postpartum cardiovascular disease risk prediction model in women incorporating reproductive and pregnancy-related predictors | BMC Medicine
Data source The Clinical Practice Research Datalink (CPRD) Gold database, which has over 19 million patient records in…
Accelerometer-derived “weekend warrior” physical activity pattern and cardiovascular disease in individuals with hypertension: a prospective cohort study | BMC Medicine
Data source and study population The UK Biobank study recruited about half of a million adults aged 37–73…
Systematic review of cost effectiveness and budget impact of artificial intelligence in healthcare
This systematic review synthesized economic evidence from 19 diverse clinical AI interventions across multiple specialties, demonstrating consistent clinical…
Mutational landscape of triple-negative breast cancer in African American women
Patient population Paired tumor and normal samples from 513 self-identified AA women with TNBC were interrogated by WES.…
Air pollution interventions for health
Health Effects Institute. State of Global Air Report 2024 www.stateofglobalair.org/resources/report/state-global-air-report-2024 (2024). World Health Organization. WHO Global Air Quality…