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Browsing Tag

blood

296 posts
MMusic
Blood, Bonds, and Bitterness: the Perverse Pervasiveness of the the Re-Recording of Bonded by Blood
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Blood, Bonds, and Bitterness: the Perverse Pervasiveness of the the Re-Recording of Bonded by Blood

  • December 13, 2025
The insidious need to rant and rave about a nagging issue I have with Exodus has been gnawing…
HHealth
New generation of CRISPR shows safer path to treating genetic diseases
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Genetic differences in surfactant proteins influence retinopathy of prematurity risk

  • December 13, 2025
A new study from the University of Oklahoma suggests that small genetic differences in two proteins – previously…
SScience
Polβ enzyme found to protect developing brain from harmful DNA mutations
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Bioluminescent tool illuminates single-cell activity in living brains

  • December 13, 2025
A decade ago, a group of scientists had the literally brilliant idea to use bioluminescent light to visualize…
HHealth
Etomidate proves safer than ketamine for emergency intubations
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Etomidate proves safer than ketamine for emergency intubations

  • December 13, 2025
Doctors treating seriously ill patients in an emergency setting may want to give the sedative etomidate, rather than ketamine,…
SScience
Researchers discover how plants produce cancer-fighting mitraphylline
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Glycation stress drives aortic stiffening through oxidative stress and senescence

  • December 13, 2025
A new research paper was published in Volume 17, Issue 11 of Aging-US on November 14, 2025, titled “Methylglyoxal-induced glycation stress…
HHealth
Fentanyl abuse impairs cardiac cell function and contributes to heart rhythm defects
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Nighttime heart attacks cause less damage due to neutrophil circadian rhythms

  • December 13, 2025
Heart attacks that occur at night are less severe than those that strike during the day. A new…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Seven blood metabolites associated with excessive daytime sleepiness
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Breast arterial calcification on mammograms predicts future heart risk

  • December 12, 2025
Routine mammograms are a critical tool for breast cancer screening. However, they may also hold crucial, potentially untapped…
NNutrition
Study: Vitamin B12: A Comprehensive Review of Natural vs Synthetic Forms of Consumption and Supplementation. Image Credit: Fida Olga / Shutterstock
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Why the form of vitamin B12 you take may matter more than your intake

  • December 12, 2025
A new scientific review weighs natural and synthetic forms of vitamin B12, revealing where methylcobalamin may outperform standard…
HHealth
Study: Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses. Image Credit: Corona Borealis Studio / Shutterstock
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Dietary restriction boosts antitumour immunity by rewiring T cell metabolism

  • December 11, 2025
By elevating ketone-driven energy pathways inside CD8+ T cells, dietary restriction steers them away from exhaustion and toward…
SScience
Newly discovered biological pathway explains clotting risk in people with type 2 diabetes
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Collaborative project seeks safer therapies for ischemia and reperfusion injury

  • December 11, 2025
Southwest Research Institute (SwRI) and Trinity University will improve a prodrug, a compound activated in the body, to…
HHealth
Anxiety and insomnia linked to reduced natural killer cell levels in young women
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Anxiety and insomnia linked to reduced natural killer cell levels in young women

  • December 11, 2025
Natural killer (NK) cells are the bodyguards of our immune system. As a first line of defense, they…
Ireland
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