Robust and accurate Bayesian inference of genome-wide genealogies for hundreds of genomes
An overview of the SINGER algorithm SINGER takes in phased WGS data and samples ARGs iteratively by adding…
Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer
de Magalhaes, J. P. How ageing processes influence cancer. Nat. Rev. Cancer 13, 357–365 (2013). Article PubMed Google…
Feasibility and clinical utility of expanded genomic newborn screening in the Early Check program
Enrollment rates Between 28 September 2023 and 10 June 2024 (~8.5 months), a total of 2,125 newborns were enrolled.…
Tip Sheet: What cancer patients need to know about tumor markers, a new cancer genetics atlas — and educational programs for students and teachers
SEATTLE — Sept. 3, 2025 — Below are summaries of recent Fred Hutch Cancer Center research findings, patient…
Tip Sheet: What cancer patients need to know about tumor markers, a new cancer genetics atlas — and educational programs for students and teachers
SEATTLE — Sept. 3, 2025 — Below are summaries of recent Fred Hutch Cancer Center research findings, patient…
Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression
James, S. L. et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354…
Mutational landscape of triple-negative breast cancer in African American women
Patient population Paired tumor and normal samples from 513 self-identified AA women with TNBC were interrogated by WES.…
Air pollution interventions for health
Health Effects Institute. State of Global Air Report 2024 www.stateofglobalair.org/resources/report/state-global-air-report-2024 (2024). World Health Organization. WHO Global Air Quality…
Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function
Integrating genetics, plasma metabolomics and dietary intakes to study ADRD etiology in long-running prospective studies We prospectively followed…
Temporal genomic dynamics shape clinical trajectory in multiple myeloma
Maura, F. et al. Moving from cancer burden to cancer genomics for smoldering myeloma: a review. JAMA Oncol.…
KidneyGenAfrica, a pan-African partnership to deliver research and training excellence in genomics of kidney disease
Precision Healthcare University Research Institute, Queen Mary University of London, London, UK Segun Fatumo, Oyesola Ojewunmi, Rebecca Camenzuli, Christopher Kintu & Claudia Langenberg…
Imaging-based multimodal profiling of single cells with STAMP
Single-cell RNA sequencing (scRNA-seq) has dramatically advanced our ability to dissect complex biological systems at cellular resolution. However,…