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Browsing Tag

Cell Death

18 posts
HHealth
Amino acid metabolism shapes the tumor immune microenvironment and therapy response
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Bacterial toxin shrinks tumors, enhances immune response in colorectal cancer study

  • January 14, 2026
A toxin secreted by cholera bacteria can inhibit the growth of colorectal cancer without causing any measurable damage…
SScience
Study forces a textbook rewrite on cell division
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Dual pathways found for centromere specification, ensuring accurate chromosome segregation

  • January 8, 2026
  Despite the immense amount of genetic material present in each cell, around three…
HHealth
Lactylation drives tumor progression and immune evasion in triple negative breast cancer
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Study reveals a therapeutic vulnerability in aggressive subtype of triple-negative breast cancer

  • December 27, 2025
Dec 26 2025 A new study published today in Science Translational Medicine by researchers at The University of…
HHealth
Amino acid metabolism shapes the tumor immune microenvironment and therapy response
Read More

Reframing the role of MCL1 in cancer signaling and metabolism

  • December 23, 2025
A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Psoriasis caused by changes in the fat metabolism of skin cells
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Psoriasis caused by changes in the fat metabolism of skin cells

  • December 11, 2025
A research team led by Erwin F. Wagner from the Medical University of Vienna has discovered a previously…
HHealth
IGF2BP3 protein drives leukemia growth by linking metabolism and RNA control
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Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

  • December 9, 2025
Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein…
HHealth
Lactylation drives tumor progression and immune evasion in triple negative breast cancer
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Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

  • December 5, 2025
Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows…
HHealth
MIT technique reveals how AI models predict protein functions
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AR3-based optogenetic strategy shows high efficacy in inducing apoptosis and antitumor effects

  • December 2, 2025
One of the hallmarks of cancer cells is their ability to evade apoptosis, or programmed cell death, through…
SScience
Researchers identify new molecular switch involved in programmed cell death
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Innate immunity and metabolic stress drive a unique form of cell death

  • December 2, 2025
In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study…
HHealth
Process of making tattoo close-up
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Tattoo ink alters immune cells and weakens some vaccine responses

  • November 27, 2025
New research reveals that tattoo pigments don’t just stay in the skin, they migrate into lymph nodes, trigger…
HHealth
Inflammation control can protect against AMD-like retinal damage
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Inflammation control can protect against AMD-like retinal damage

  • November 22, 2025
University of Minnesota Medical School researchers have shown that reducing chronic inflammation can significantly protect against age-related macular…
Ireland
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