Precise DNA base editing using AlphaFold3-based contact modelling
Anzalone, A. V., Koblan, L. W. & Liu, D. R. Genome editing with CRISPR-Cas nucleases, base editors, transposases…
US lab discovers new way to build powerful magnets without rare earths
Scientists at the Ames National Laboratory in the U.S. have developed a systematic path to the discovery of…
Sleep chart of biological ageing clocks in middle and late life
The MULTI Consortium The MULTI Consortium is an ongoing initiative to integrate and consolidate existing multi-organ and multi-omics…
AI-based chest X-ray prioritization in the lung cancer diagnostic pathway: the LungIMPACT randomized controlled trial
This large, multisite randomized study has shown that AI prioritization of CXRs did not improve the speed of…
NutriMatch: harmonizing food composition databases with large language models for enhanced nutritional prediction
Data collection We utilized data from the 10K Project, a prospective human cohort study involving over 10,000 healthy…
ImmunoStruct enables multimodal deep learning for immunogenicity prediction
Gupta, M. et al. Recent advances in cancer vaccines: challenges, achievements, and futuristic prospects. Vaccines 10, 2011 (2022).…
A universal entropic pulling force caused by binding
Entropic force in a diatomic molecule To illustrate the concept of entropic force, we begin with a simple…
Comparison of clinical hysterectomy indications with ai-based recommendations: a prospective study
In this study, the demographic characteristics, clinical histories, and surgical outcomes of 87 women who underwent hysterectomy were…
Genetic controllers for enhancing the evolutionary longevity of synthetic gene circuits in bacteria
Modelling and quantifying gene circuit evolution We develop an ordinary differential equation model of host-circuit interactions31,33 and augment…
Quantum computing for faster enzyme discovery and engineering
Nielsen, M. A. & Chuang, I. L. Quantum Computation and Quantum Information: 10th Anniversary Edition (Cambridge Univ. Press,…
Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation
Nonparametric baselines We design two nonparametric baselines that we refer to as perturbed mean and matching mean. Perturbed…
Clone copy number diversity is linked to survival in lung cancer
The ALPACA algorithm We introduce ALPACA, an algorithm to infer allele-specific copy-number profiles of every tumour clone, given…