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Browsing Tag

DNA

160 posts
SScience
Evolutionary mutation in cGAS enhances naked mole-rat DNA repair
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Vibration-induced local vortices enable low-cost biomolecular condensate engineering

  • December 23, 2025
A research group led by Professor Hiroaki SUZUKI and Takeshi HAYAKAWA from the Faculty of Science and Engineering…
SScience
New insights reveal persistent genome structure during cell division
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Opposing protein forces fine tune mRNA stability in human cells

  • December 17, 2025
A newly revealed molecular tug-of-war may have implications for better understanding how a multitude of diseases and disorders…
MMental health
Why many mental health conditions may be more alike than we thought
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Why many mental health conditions may be more alike than we thought

  • December 16, 2025
Published on 16/12/2025 – 7:01 GMT+1 Different mental health conditions may have far more in common at a…
HHealth
New study reveals a 25-year rise in alcohol-induced mortality
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New insights into alcohol-related DNA damage and cancer risk

  • December 16, 2025
Alcohol consumption leads to the formation of a toxic compound called acetaldehyde, which damages DNA. A research team…
SScience
Refined DNA sequencing tool reveals hidden mutations behind aging and cancer
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Researchers develop powerful tools for microbiome research advancement

  • December 13, 2025
The microscopic organisms that fill our bodies, soils, oceans and atmosphere play essential roles in human health and…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
NNutrition
Study: Vitamin B12: A Comprehensive Review of Natural vs Synthetic Forms of Consumption and Supplementation. Image Credit: Fida Olga / Shutterstock
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Why the form of vitamin B12 you take may matter more than your intake

  • December 12, 2025
A new scientific review weighs natural and synthetic forms of vitamin B12, revealing where methylcobalamin may outperform standard…
HHealth
Amino acid metabolism shapes the tumor immune microenvironment and therapy response
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Researchers discover the enzyme responsible for chromothripsis in cancer

  • December 11, 2025
University of California San Diego researchers have discovered the enzyme responsible for chromothripsis, a process in which a…
SScience
Study: Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency. Image Credit: Julien Tromeur / Shutterstock
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Nanoflower-treated stem cells deliver healthier mitochondria to stressed cells

  • December 10, 2025
By engineering nanomaterials that boost mitochondrial biogenesis, researchers show how stem cells can become powerful “mitochondrial biofactories,” offering…
HHealth
Letter to the Editor: Improved Human Skin Vitamin C Levels and Skin Function after Dietary Intake of Kiwifruit: A High-Vitamin-C Food. Image Credit: Meomeow / Shutterstock
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Kiwifruit intake boosts vitamin C in skin and supports dermal structure

  • December 8, 2025
By directly measuring vitamin C inside human skin, researchers show that diet can boost skin vitamin C content…
IIreland
Man convicted of trying to strangle woman in park says DNA evidence should not have been introduced at trial – The Irish Times
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Man convicted of trying to strangle woman in park says DNA evidence should not have been introduced at trial – The Irish Times

  • December 4, 2025
A man jailed for attempting to strangle a woman in a Dublin park has argued that DNA evidence…
SScience
Evolutionary mutation in cGAS enhances naked mole-rat DNA repair
Read More

New method reveals how human cells initiate DNA replication

  • December 3, 2025
When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process…
Ireland
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