PRDM16 regulates the balance between proliferation and maturation in human cardiomyocytes
Understanding how heart muscle cells stop dividing and acquire the characteristics needed to sustain lifelong cardiac function remains…
Scientists uncover cellular mechanism behind congenital heart defects
Congenital heart disease affects approximately two in every 100 newborns globally. But why do they occur? An important…
Advances in X chromosome inactivation open therapeutic opportunities for X-linked genetic disorders
A new review explores how advances in understanding X chromosome inactivation (XCI) are creating potential therapeutic opportunities for…
St. Jude scientists uncover regulatory mechanism for crucial developmental pathway
St. Jude Children’s Research Hospital scientists uncovered a regulatory mechanism for signaling of Sonic Hedgehog (SHH), a pathway…
Base Editing reveals Human Embryo Development ‘Master Gene’
For the first time, researchers have used a genome editing technique called base editing to identify a master…
Autophagy Decline in Older Moms Halts Embryo Development
Summary: Researchers unmasked a hidden metabolic mechanism that explains why advanced maternal age (AMA) impairs female fertility and…
China sends synthetic human embryos to space in first test of how life begins off Earth
China has launched a new experiment to see how the earliest stages of human development might unfold in…
UC Davis scientists identify protein key to male fertility
The causes of male infertility can be hard to diagnose, with many tests failing to detect genetic defects.…
Study connects ultra-processed diets to fertility and embryo development
Eating large amounts of ultra-processed food (UPF) is linked not only to reduced fertility in men, but also…
Sperm RNA aging shift that may explain paternal age effects
A newly revealed “aging cliff” in sperm RNA marks a conserved molecular transition from youth to later life,…
New computational method reconstructs how cells decide their fate
Researchers from Kyushu University have developed an innovative computational method, called ddHodge, that can reconstruct the complex dynamics…
Study uncovers role of mechanical forces in human gastrulation
Only two weeks after fertilization, the first sign of the formation of the 3 axes of the human…