From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes
Strain culture and DNA extraction We used a collection of S. cerevisiae isolates that were previously sequenced using…
Fueling chromosomal gene diversification and artificial evolution with CRISPR | Genome Biology
Wilson DS, Keefe AD. Random mutagenesis by PCR. Curr Protoc Mol Biol. 2001;51:8–3. Google Scholar Reetz MT, Wu…
Clarifying Uncertain Genetic Tests in Cancer Treatment
Cancer treatment is becoming more personalised. By considering a patient’s unique genetic and molecular profile, along with their…
Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression
James, S. L. et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354…
Methods and applications of in vivo CRISPR screening
Auton, A. et al. A global reference for human genetic variation. Nature 526, 68–74 (2015). PubMed Google Scholar …