Molecular map reveals how Down syndrome alters brain development
Scientists at UCLA have created one of the first cellular-resolution molecular maps detailing how Down syndrome alters human…
Epigenome proteins shape dynamic gene expression beyond simple on-off
A new study finds the proteins responsible for controlling which genes are expressed in a genome do more…
High-resolution study maps molecular differences across six human cortical regions
A new analysis of individual brain cells across several human brain regions reveals subtle but widespread differences in…
Parents’ intake of sugar substitutes may influence offspring gut biology, study finds
A new mouse study suggests that sweeteners consumed by parents may reshape gut bacteria, microbial metabolites, and metabolic…
Pseudogene lncRNAs regulate cancer stem cell behavior and signaling
Cancer stem cells (CSCs), a critical subpopulation within tumors, drive cancer initiation, progression, metastasis, relapse, and resistance to…
How could bisphenol A raise depression risk? Study identifies six key molecular targets
Researchers combined genetic epidemiology, transcriptomics, molecular docking, and mouse experiments to show how a common endocrine-disrupting chemical may…
Alcohol impacts gene expression differently across brain regions
Erica Periandri and Gabor Egervari, from Washington University in St. Louis, led a study to explore how alcohol exposure in male mice influences gene expression…
Largest genetic study classifies 14 psychiatric disorders into five major groups
Although mental disorders have multifactorial causes, genetics can explain some of them, yet this field remains largely unexplored…
New HIV-seq tool advances understanding of persistent viral reservoirs
For people living with human immunodeficiency virus (HIV), life-saving antiretroviral therapy keeps their HIV-infected immune cells from making…
New method isolates true transcription factor targets in tuberculosis bacteria
Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene expression.…
Scientists put forward a new theory of brain development
Your brain begins as a single cell. When all is said and done, it will house an incredibly…
A multi-dimensional framework for establishing and managing a genomic newborn screening program
The above-described methodology resulted in a multi-dimensional framework for a gNBS program consisting of 18 screening criteria (Table 1)…