SOX2 drives progression and therapy resistance in advanced prostate cancer
Prostate cancer remains a global health challenge, ranking as the second most common malignancy among men. While early-stage…
Study reveals genome rewiring mechanism driving mantle cell lymphoma
Translocations are chromosomal “cut and paste” errors that drive many lymphomas, a type of blood cancer and the…
Denisovan DNA May Have Helped Ancient Humans Survive in Americas
Thousands of years ago, ancient Homo sapiens undertook a treacherous journey, crossing hundreds of km of ice over…
Single-cell proteomic analysis uncovers hidden layers of blood cell formation
In the past decade there has been significant interest in studying the expression of our genetic code down…
Yale researchers uncover new RNA editing tools for safer genetic surgery
The ability to correct disease-causing genetic mistakes using genome editors holds great promise in medicine, but it is…
New genome-wide CRISPR screening tool boosts natural killer cells to fight cancer
Natural killer (NK) cells became markedly better at killing cancer cells after scientists removed key gene targets identified…
Breakthroughs in diagnosis and therapy for transthyretin amyloidosis
Transthyretin amyloidosis (ATTR) is caused by the misfolding and aggregation of the transthyretin (TTR) protein, leading to multi-organ…
Genetic variants influencing vitamin D synthesis, metabolism, and transport
From skin tone to rare mutations, scientists uncover how your genes influence vitamin D levels, and why standard…
ChronODE method offers precision in timing gene therapy treatments
A Yale research team has created a new computer tool that can pinpoint when exactly genes turn on…
Missing messenger RNA fragments unlock new immunotherapy targets in pediatric brain tumors
A new study, led by researchers at Children’s Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA…
Lactylation drives tumor progression and immune evasion in triple negative breast cancer
Breast cancer maintains its position as the most prevalent malignancy in women worldwide, with triple-negative breast cancer (TNBC)…
New generation of CRISPR shows safer path to treating genetic diseases
A new generation of CRISPR technology developed at UNSW Sydney offers a safer path to treating genetic diseases…