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Browsing Tag

Genes

125 posts
HHealth
Study: Feasibility and outcomes of the DNA Screen nationwide adult genomic screening pilot. Image Credit: Westlight / Shutterstock
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Genomic screening uncovers hidden cancer and heart disease risk in young adults

  • January 20, 2026
A large Australian pilot shows that testing healthy young adults for high-risk genes can reveal serious disease risk…
HHealth
Less education associated with faster aging and health inequality
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Single-cell technique maps pre-malignant gene mutations in solid tissues

  • January 17, 2026
A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the…
HHealth
Rapid neuronal evolution linked to high prevalence of autism in humans
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Age-related sperm changes at imprint regions linked to autism risk

  • January 16, 2026
A new research paper was published in Volume 17, Issue 12 of Aging-US on December 29, 2025, titled “Age-specific DNA methylation…
HHealth
Pathogenic bacteria can block gut’s natural defense to spread infection
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Genomic analysis reveals diverse, drug-resistant E. coli in diabetic foot infections

  • January 13, 2026
New research led by King’s College London, in collaboration with the University of Westminster, has shed light on…
SScience
Evolutionary mutation in cGAS enhances naked mole-rat DNA repair
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Key protein in the tuberculosis bacterium helps protect itself from foreign DNA

  • January 10, 2026
Researchers at the Indian Institute of Science (IISc), with collaborators from the Institute of Mathematical Sciences (IMSc), have…
SScience
Common painkillers ibuprofen and paracetamol found to fuel antibiotic resistance
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Sub-lethal water disinfection can unintentionally boost the spread of antibiotic resistance

  • January 9, 2026
The study reveals that environmental stressors do not merely kill bacteria; they can also prime surviving cells to…
SScience
New screening method boosts efficiency and accuracy of CAST genome editing
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A precise tool to halt viral protein production

  • January 7, 2026
Across all domains of life, immune defenses foil invading viruses by making it impossible for the viruses to…
SScience
Electrical stimulation predicts recovery potential after acute nerve injuries
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New computational method reconstructs how cells decide their fate

  • December 31, 2025
Researchers from Kyushu University have developed an innovative computational method, called ddHodge, that can reconstruct the complex dynamics…
AArts and design
Photographer made it his life work to track down amazing doppelgängers. Here are his best finds.
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Photographer made it his life work to track down amazing doppelgängers. Here are his best finds.

  • December 24, 2025
When photographer François Brunelle was young, everyone told him he looked exactly like Mr. Bean. As a younger…
SScience
UIC researchers discover an important cellular mechanism that drives aging
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Researchers create the most detailed 3D maps of the human genome

  • December 23, 2025
In a landmark effort to understand how the physical structure of our DNA influences human biology, Northwestern investigators…
SScience
Refined DNA sequencing tool reveals hidden mutations behind aging and cancer
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Researchers develop powerful tools for microbiome research advancement

  • December 13, 2025
The microscopic organisms that fill our bodies, soils, oceans and atmosphere play essential roles in human health and…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
Ireland
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