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Browsing Tag

inflammation

131 posts
HHealth
Amino acid metabolism shapes the tumor immune microenvironment and therapy response
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Inflammation and immune suppression fuel aggressive SCLC behavior and spread

  • December 30, 2025
Small cell lung cancer (SCLC) is one of the most aggressive forms of lung cancer, with a five-year…
NNutrition
Lard can actually keep you fit and feeling more comfortable, Chinese study finds
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Lard can actually keep you fit and feeling more comfortable, Chinese study finds

  • December 24, 2025
Consuming a diet with a moderate amount of lard can decrease both fat accumulation and inflammation in body…
HHealth
Blocking platelet-activating factor reduces liver damage in cirrhosis
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Blocking platelet-activating factor reduces liver damage in cirrhosis

  • December 21, 2025
Researchers from Miguel Hernández University of Elche (UMH) in Spain have identified an effective strategy to reduce structural…
NNutrition
The 7 Best Foods to Fight Inflammation
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The 7 Best Foods to Fight Inflammation

  • December 18, 2025
Inflammation is a natural process that plays a key role in your body’s immune response—but it has a…
HHealth
New generation of CRISPR shows safer path to treating genetic diseases
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Genetic differences in surfactant proteins influence retinopathy of prematurity risk

  • December 13, 2025
A new study from the University of Oklahoma suggests that small genetic differences in two proteins – previously…
HHealth
Fentanyl abuse impairs cardiac cell function and contributes to heart rhythm defects
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Nighttime heart attacks cause less damage due to neutrophil circadian rhythms

  • December 13, 2025
Heart attacks that occur at night are less severe than those that strike during the day. A new…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Psoriasis caused by changes in the fat metabolism of skin cells
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Psoriasis caused by changes in the fat metabolism of skin cells

  • December 11, 2025
A research team led by Erwin F. Wagner from the Medical University of Vienna has discovered a previously…
SScience
SIRT3 deficiency worsens eustachian tube dysfunction during middle-ear infection
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SIRT3 deficiency worsens eustachian tube dysfunction during middle-ear infection

  • December 10, 2025
Middle-ear infections caused by Gram-negative bacteria remain among the most common pediatric illnesses worldwide. When the eustachian tube-responsible…
HHealth
Study: Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control. Image Credit: Ahmet Misirligul / Shutterstock
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Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

  • December 10, 2025
A microbial metabolite long linked to cardiovascular risk emerges as a surprising ally against metabolic inflammation, revealing how…
HHealthcare
BioAge shows promise with new drug BGE-102 in early trial
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BioAge shows promise with new drug BGE-102 in early trial

  • December 8, 2025
The company expands its Phase 1 trial after early signals show BGE-102’s potential to address inflammation beyond the…
HHealth
Intravenous iron shows safe and beneficial outcomes for patients with bacterial infection and anemia
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Intravenous iron shows safe and beneficial outcomes for patients with bacterial infection and anemia

  • December 7, 2025
Treatment with intravenous (IV) iron significantly improved survival and increased hemoglobin levels in patients with iron-deficiency anemia who…
Ireland
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