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Browsing Tag

Liver

65 posts
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
NNutrition
Study: Vitamin B12: A Comprehensive Review of Natural vs Synthetic Forms of Consumption and Supplementation. Image Credit: Fida Olga / Shutterstock
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Why the form of vitamin B12 you take may matter more than your intake

  • December 12, 2025
A new scientific review weighs natural and synthetic forms of vitamin B12, revealing where methylcobalamin may outperform standard…
HHealth
New study reveals a 25-year rise in alcohol-induced mortality
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Frequency and quantity of alcohol consumption influence cancer risk

  • December 11, 2025
As Americans gear up for the holiday season, new research offers a timely reminder to reflect on the…
HHealth
Cancer surgeon shares 6 dietary habits to prevent stomach cancer: Prioritise fresh fruits and vegetables for gut health
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Cancer surgeon shares 6 dietary habits to prevent stomach cancer: Prioritise fresh fruits and vegetables for gut health

  • December 10, 2025
Stomach cancer, also known as gastric cancer, is one of the most common cancers in the world. According…
HHealth
Study: Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control. Image Credit: Ahmet Misirligul / Shutterstock
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Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

  • December 10, 2025
A microbial metabolite long linked to cardiovascular risk emerges as a surprising ally against metabolic inflammation, revealing how…
HHealth
Study: The relationship between serum total alkaline phosphatase and risk of osteoporosis: a cross-sectional study. Image Credit: Javier Regueiro / Shutterstock
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Routine blood test may flag hidden osteoporosis risk, study finds

  • December 9, 2025
Common blood test results may offer an early clue to bone loss, suggesting that alkaline phosphatase levels could…
HHealth
Calcium supplements do not prevent pre-eclampsia, large trials show no meaningful benefit
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Calcium supplements do not prevent pre-eclampsia, large trials show no meaningful benefit

  • December 8, 2025
A new Cochrane systematic review of 10 randomised trials involving over 37,000 pregnant women found that calcium supplementation…
SScience
Understanding how lipids activate LC3-associated phagocytosis
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New C-COMPASS software opens spatial proteomics and lipidomics to non-coders

  • December 4, 2025
A new tool developed by Helmholtz Munich and the German Center for Diabetes Research and the University of…
HHealth
Genetic mutation in some East Asians linked to aldehyde storm and increased liver disease risk
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Sugar alcohol sorbitol may increase the risk of developing steatotic liver disease

  • December 3, 2025
Sweeteners such as aspartame, found in Equal packets, sucralose (Splenda), or sugar alcohols are often seen as healthier…
HHealth
Polβ enzyme found to protect developing brain from harmful DNA mutations
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New technique overcomes technological barrier in 3D brain imaging

  • December 2, 2025
Scientists at the Swiss Light Source SLS have succeeded in mapping a piece of brain tissue in 3D…
HHealth
Large-scale analysis offers insights into sporadic nature of chikungunya virus outbreaks
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RFK Jr. wants to delay the hepatitis B vaccine. Here’s what parents need to know.

  • December 2, 2025
Working out of a tribal-owned hospital in Anchorage, Alaska, liver specialist Brian McMahon has spent decades treating the…
HHealthcare
NewLimit 'close' to clinic-ready epigenetic reprogramming therapy
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NewLimit ‘close’ to clinic-ready epigenetic reprogramming therapy

  • November 27, 2025
Liver rejuvenation program produces a ‘lead payload’ as biotech begins its journey towards human clinical trials. After several…
Ireland
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