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Browsing Tag

Lungs

21 posts
HHealth
Metabolic health plays larger role than weight gain in pregnancy outcomes
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Study explores how shared cells influence health across generations

  • January 23, 2026
During pregnancy, maternal and fetal cells migrate back and forth across the placenta, with fetal cells entering the…
HHealth
Targeting bacterial communication may offer antibiotic-free wound therapy
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Facial wound secrets revealed for scarless repair

  • January 22, 2026
Tweaking a pattern of wound healing established millions of years ago may enable scar-free injury repair after surgery…
HHealth
Study: Paracetamol or ibuprofen? A pilot study comparing rescue therapy for PDA in preterm infants within the first month. Image Credit: Jana Kollarova / Shutterstock
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Study finds no safety or efficacy gap between paracetamol and ibuprofen for neonatal PDA

  • January 22, 2026
A small but rigorous randomized trial suggests paracetamol may be a feasible alternative to ibuprofen for late PDA…
HHealth
New generation of CRISPR shows safer path to treating genetic diseases
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Genetic differences in surfactant proteins influence retinopathy of prematurity risk

  • December 13, 2025
A new study from the University of Oklahoma suggests that small genetic differences in two proteins – previously…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Cystic fibrosis patients on triple-drug therapy can safely reduce daily lung treatments
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Enterprise Therapeutics publishes results of Phase 1 study of ETD001, a novel inhaled ENaC blocker for treatment of Cystic Fibrosis, in The Journal of Cystic Fibrosis

  • December 9, 2025
Enterprise Therapeutics Ltd (Enterprise), a biopharmaceutical company dedicated to the discovery and development of novel therapies to improve…
HHealth
Lactylation drives tumor progression and immune evasion in triple negative breast cancer
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Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

  • December 5, 2025
Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows…
HHealth
Cystic fibrosis patients on triple-drug therapy can safely reduce daily lung treatments
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Cystic fibrosis patients on triple-drug therapy can safely reduce daily lung treatments

  • December 5, 2025
A new multi-site study led by researchers at CU Anschutz shows that people with cystic fibrosis (CF) who…
HHealth
Experimental drug engasertib shows promise for treating inherited bleeding disorder
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Experimental drug engasertib shows promise for treating inherited bleeding disorder

  • November 27, 2025
Hereditary hemorrhagic telangiectasia (HHT) is the second most common inherited bleeding disorder worldwide, affecting 1 in 3,800 persons.…
HHealth
Amino acid metabolism shapes the tumor immune microenvironment and therapy response
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Protein linked to cancer plays key role in wound healing

  • November 8, 2025
When doctors detect elevated levels of SerpinB3 in a blood test, it can signal that something is seriously…
HHealth
Extended apixaban therapy lowers recurrent VTE in patients with provoked events and enduring risk factors
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Improving diagnosis, treatment and follow-up care for pulmonary embolism

  • October 31, 2025
Pulmonary embolism (PE), a type of blood clot in the lungs, sends more than half a million people…
HHealth
Gut bacteria provide key to identifying colorectal cancer from stool samples
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New biofilm discovery may pave way to undermining antibiotic-resistant Pseudomonas

  • October 29, 2025
The bacterium known as Pseudomonas aeruginosa is an unwelcome visitor in the human body. Serious infections can result…
Ireland
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