Uppsala researchers develop Trojan horse approach for medulloblastoma treatment
The malignant pediatric brain tumor medulloblastoma is driven by proteins deep within the cancer cells, for which there…
precision DNA repair may hold clues for human aging
The bowhead whale’s remarkable lifespan and low cancer risk stem from a finely tuned DNA repair system driven…
Two analgesic drugs may one day be repurposed as anti-tumor therapies
Peripheral afferent neurons – nerves that send signals from all areas of the body to the central nervous…
Cleveland Clinic team uncovers genetic link to osteosarcoma
Researchers at Cleveland Clinic Children’s have helped identify a previously unknown gene that increases the risk of developing…
Boosting the immune system to prevent cancer recurrence and improve survival
In experiments with mouse models of breast, pancreatic, and muscle cancers, researchers at Johns Hopkins All Children’s Hospital…
Calcium-induced release identified as key driver of dangerous muscle disorders
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without…
ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation
Background and aims Despite advancements in diagnostic and therapeutic strategies, hepatocellular carcinoma (HCC) remains a leading cause of…
Targeting a sugar metabolism pathway offers hope for treating rare and aggressive childhood cancer
A new study delving into the genetic drivers of a rare and aggressive childhood cancer called Malignant Peripheral…