Metabolism

Genetic mutation in some East Asians linked to aldehyde storm and increased liver disease risk

January 14, 2026

Researchers at McMaster University are leading preclinical studies into a novel drug candidate developed by Espervita Therapeutics that has the potential to prevent and reverse liver fibrosis – a dangerous, disease-induced build-up of…

HHealth

Obesity study reveals gut fat's unique inflammatory role and immune cell richness

January 13, 2026

Abdominal fat is not a uniform tissue. A new study from Karolinska Institutet, Steno Diabetes Center Copenhagen, and…

HHealth

Amino acid metabolism shapes the tumor immune microenvironment and therapy response

December 23, 2025

A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD…

HHealth

December 14, 2025

Summary: Blood sugar patterns and dietary choices play a significant role in how well adults sleep. Individuals with…

HHealth

Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .

December 12, 2025

New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…

NNutrition

Study: Vitamin B12: A Comprehensive Review of Natural vs Synthetic Forms of Consumption and Supplementation. Image Credit: Fida Olga / Shutterstock

December 12, 2025

A new scientific review weighs natural and synthetic forms of vitamin B12, revealing where methylcobalamin may outperform standard…

HHealth

Psoriasis caused by changes in the fat metabolism of skin cells

December 11, 2025

A research team led by Erwin F. Wagner from the Medical University of Vienna has discovered a previously…

HHealth

Study: Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses. Image Credit: Corona Borealis Studio / Shutterstock

December 11, 2025

By elevating ketone-driven energy pathways inside CD8+ T cells, dietary restriction steers them away from exhaustion and toward…

SScience

Study: Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency. Image Credit: Julien Tromeur / Shutterstock

December 10, 2025

By engineering nanomaterials that boost mitochondrial biogenesis, researchers show how stem cells can become powerful “mitochondrial biofactories,” offering…

HHealth

Study: Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control. Image Credit: Ahmet Misirligul / Shutterstock

December 10, 2025

A microbial metabolite long linked to cardiovascular risk emerges as a surprising ally against metabolic inflammation, revealing how…

HHealth

Finnish research pinpoints a higher risk among cohabiting survivors

December 4, 2025

Strong social relationships, particularly high-quality marriages, may help protect against obesity by influencing a complex communication system between…

HHealth

How the gut microbiome links obesity to colorectal cancer

November 28, 2025

Study: From obesity to cancer: Gut microbiome mechanisms, biomarkers, and U.S. public health strategies. Image Credit: Shutterstock AI…

Preclinical study reveals potential new treatment for severe liver fibrosis

Obesity study reveals gut fat’s unique inflammatory role and immune cell richness

Reframing the role of MCL1 in cancer signaling and metabolism

Blood Sugar Patterns Strongly Linked to Sleep Quality

Scientists outline how organ rejuvenation strategies could solve the donor shortage

Why the form of vitamin B12 you take may matter more than your intake

Psoriasis caused by changes in the fat metabolism of skin cells

Dietary restriction boosts antitumour immunity by rewiring T cell metabolism

Nanoflower-treated stem cells deliver healthier mitochondria to stressed cells

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Emotional support in marriage associated with lower BMI and fewer food cravings

How the gut microbiome links obesity to colorectal cancer