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Browsing Tag

Metformin

15 posts
HHealth
Amino acid metabolism shapes the tumor immune microenvironment and therapy response
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Sex-specific analysis uncovers unique disease pathways and treatment implications

  • January 31, 2026
Biological differences between women and men led to variations in the appearance and progression of many diseases, which…
MMedication
Inside Jelly Roll’s Radical Weight-Loss and Health Transformation
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Inside Jelly Roll’s Radical Weight-Loss and Health Transformation

  • January 9, 2026
JELLY ROLL FISTS a handful of loose skin beneath his black compression shirt and moves it from his…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealthcare
Yahoo news home
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Scientists Just Discovered a Surprising Side Effect of a Popular Diabetes Drug

  • November 23, 2025
Reviewed by Dietitian Emily Lachtrupp, M.S., RD Getty Images. EatingWell Design. Key Points Metformin may blunt blood vessel…
MMedication
Metformin
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Metformin, Meaning, Uses, Latest News

  • November 14, 2025
Metformin is an anti-diabetic medication (biguanide). Read more about Metformin, Meaning, Uses, Latest News. Metformin Latest News Metformin…
FFitness
Diabetes drug cancelling your workout gains? Study explains why |
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Diabetes drug cancelling your workout gains? Study explains why |

  • November 12, 2025
A Rutgers study reveals that metformin, a common diabetes drug, may counteract the benefits of exercise. Researchers found…
HHealth
Faster progression to severe diabetes observed in people with learning disabilities
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Metformin shows promise in treating AFib recurrence after ablation

  • November 11, 2025
People with atrial fibrillation (AFib) and obesity may have fewer episodes of AFib after ablation if they take the diabetes medication metformin…
FFitness
The Independent
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Scientists warn common diabetes drug may be cancelling out benefits of exercise

  • November 8, 2025
A widely prescribed diabetes drug may be blunting the beneficial effects of exercise in patients, a new study…
HHealthcare
New research highlights combined impact of genes and lifestyle on dilated cardiomyopathy
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Diabetes drug blunts exercise-induced health improvements

  • November 8, 2025
A widely prescribed diabetes drug may be sabotaging one of the most trusted strategies for preventing the disease:…
FFitness
The Independent
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Scientists warn common diabetes drug may be cancelling out benefits of exercise

  • November 7, 2025
A widely prescribed diabetes drug may be blunting the beneficial effects of exercise in patients, a new study…
HHealth
Couple of senior man and woman eating burgers
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How diet affects aging metabolism differently for men and women

  • November 7, 2025
Researchers have uncovered striking sex-based differences in how diet influences metabolism with age, revealing that plant proteins and…
HHealth
Study explores how losing the Y chromosome fuels bladder cancer aggressiveness
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Discovery explains why women face higher risk of Alzheimer’s and multiple sclerosis

  • October 16, 2025
New research by UCLA Health has identified a sex-chromosome linked gene that drives inflammation in the female brain,…
Ireland
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