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Browsing Tag

Mitochondria

30 posts
HHealth
New generation of CRISPR shows safer path to treating genetic diseases
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New discovery may aid in early detection of rare genetic disease

  • January 28, 2026
Virginia Tech researchers discovered an indication hidden in the brain that may help doctors identify children suffering from…
SScience
MIT technique reveals how AI models predict protein functions
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Customizable protein platforms offer new hope for cancer treatment

  • January 20, 2026
Precise methods for shredding or repairing and replacing specific cancer-causing proteins in a malignant cell, developed at the…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
SScience
Study: Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency. Image Credit: Julien Tromeur / Shutterstock
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Nanoflower-treated stem cells deliver healthier mitochondria to stressed cells

  • December 10, 2025
By engineering nanomaterials that boost mitochondrial biogenesis, researchers show how stem cells can become powerful “mitochondrial biofactories,” offering…
TTechnology
a) Simultaneous annular dark field (ADF) image of the mitochondria. b) EELS elemental map showing that the areas in purple correspond to the presence of Ca
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High-resolution EELS mapping of mitochondria

  • December 3, 2025
Sponsored Content by Gatan, Inc.Reviewed by Olivia FrostDec 3 2025 The chemical composition of cryogenically frozen materials that…
HHealth
MIT technique reveals how AI models predict protein functions
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AR3-based optogenetic strategy shows high efficacy in inducing apoptosis and antitumor effects

  • December 2, 2025
One of the hallmarks of cancer cells is their ability to evade apoptosis, or programmed cell death, through…
SScience
Researchers identify new molecular switch involved in programmed cell death
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Innate immunity and metabolic stress drive a unique form of cell death

  • December 2, 2025
In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study…
SScience
Endoplasmic reticulum controls cell movement to repair tissue gaps
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New method can stop or reverse the decline of cellular energy production

  • November 22, 2025
Biomedical researchers at Texas A&M University may have discovered a way to stop or even reverse the decline…
SScience
Yahoo news home
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“Living Fossil” Discovered by Accident Could Reshape Tree of Life

  • November 21, 2025
It’s not uncommon for a new species to be discovered among existing collections; it’s rare that the new…
SScience
The Blueprint
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Nanotech method loads stem cells with mitochondria to revive cells

  • November 20, 2025
Scientists at Texas A&M University say they may have found a way to stop or even reverse the…
SScience
Dysfunctional mitochondria shown to initiate the onset of Parkinson's
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Dysfunctional mitochondria shown to initiate the onset of Parkinson’s

  • November 17, 2025
For decades, scientists have known that mitochondria, which produce energy inside our cells, malfunction in Parkinson’s disease. But…
SScience
Breakthroughs in diagnosis and therapy for transthyretin amyloidosis
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Multiple protein forms from a single gene offer fresh insight into rare disease mechanisms

  • November 8, 2025
Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of…
Ireland
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