Determining the value of genomics in healthcare
Stark, Z. et al. Integrating genomics into healthcare: a global responsibility. Am. J. Hum. Genet 104, 13–20 (2019).…
C-terminus-dependent detection of lysosomal alpha-synuclein in nigral Parkinson’s disease human brain neurons | Molecular Neurodegeneration
Maroteaux L, Campanelli JT, Scheller RH. Synuclein – a neuron-specific protein localized to the nucleus and presynaptic nerve-terminal.…
A full life cycle biological clock based on routine clinical data and its impact in health and diseases
Study populations The China Health Aging Investigation (CHAI), as a project of the International Consortium of Digital Twin…
Dual-function MgSrCeAl-LDH nanosheets enable both ROS clearance and enhanced angiogenesis for myocardial ischemia/reperfusion injury therapy | Journal of Nanobiotechnology
Materials Magnesium nitrate hexahydrate (Mg(NO3)2·6H2O, > 99.0%), aluminum nitrate nonahydrate (Al(NO3)2·9H2O, > 99.0%), strontium nitrate (Sr(NO3)2, > 99.0%), cerium nitrate hexahydrate…
Entering the era of precision medicine to treat amyotrophic lateral sclerosis | Molecular Neurodegeneration
Goutman SA, Hardiman O, Al-Chalabi A, Chió A, Savelieff MG, Kiernan MC, Feldman EL. Emerging insights into the…
Brain somatic mutations in Alzheimer’s disease: linking genetic mosaicism to neurodegeneration | Molecular Neurodegeneration
Zhang XX, Tian Y, Wang ZT, Ma YH, Tan L, Yu JT. The epidemiology of alzheimer’s disease modifiable…
Generative artificial intelligence in medicine
Bengesi, S. et al. Advancements in generative AI: a comprehensive review of GANs, GPT, autoencoders, diffusion model, and…
Rapid in situ microwave-assisted fabrication of ultrabright near-infrared probe for low-dose in vivo inflammatory imaging | Journal of Nanobiotechnology
Preparation and characterization of Ag2S super NPs Microwaves, a kind of nonionizing electromagnetic energy, exhibits a spectral frequency…
Synthetic lethality in cancer drug discovery: challenges and opportunities
Hartwell, L. H., Szankasi, P., Roberts, C. J., Murray, A. W. & Friend, S. H. Integrating genetic approaches…
Association between the English National Health Service Diabetes Prevention Programme and incident multiple long-term conditions
Study design and data sources The data used in this study are collected and used in line with…
Feasibility and clinical utility of expanded genomic newborn screening in the Early Check program
Enrollment rates Between 28 September 2023 and 10 June 2024 (~8.5 months), a total of 2,125 newborns were enrolled.…
Air pollution interventions for health
Health Effects Institute. State of Global Air Report 2024 www.stateofglobalair.org/resources/report/state-global-air-report-2024 (2024). World Health Organization. WHO Global Air Quality…