MSK scientists shed new light on a tumor’s earliest moments
Scientists at Memorial Sloan Kettering Cancer Center (MSK) and their colleagues are shedding new light on a tumor’s…
Toxic RNA drives progressive heart damage in myotonic dystrophy
Myotonic dystrophy type 1 (DM1) is the most common cause of adult-onset muscular dystrophy, a genetic disorder that…
Genomic study advances prioritization of variants in cancer diagnostics
Hiroshima University researchers have developed a practical framework to identify candidate pathogenic variants hidden among the large number…
Gene mutation that aids high-altitude survival could repair myelin sheath damage
A genetic mutation that helps animals like yaks and Tibetan antelopes survive at high altitudes may hold the key to repairing…
Transposable elements cause majority of lethal mutations in fruit flies
Most lethal mutations in wild fruit flies are driven by newly transferred jumping genes, not small DNA errors,…
Microbial ecosystems influence success of cancer checkpoint immunotherapy
Immune checkpoint inhibitors targeting PD-1 and PD-L1 have revolutionized cancer therapy, delivering long-term survival benefits in several malignancies.…
AI trained on 9 trillion DNA letters predicts harmful mutations and designs new genomes
Trained on genomic data spanning the tree of life, Evo 2 reveals how artificial intelligence can decode the…
Novel lipid bubble delivery shows promise for ALS treatment
A researcher at the University of Missouri has made a promising breakthrough in the quest to help people…
MULTI-evolve accelerates protein engineering with machine learning
The search space for protein engineering grows exponentially with complexity. A protein of just 100 amino acids has…
Antibody feedback reshapes B cell selection during immune response
A collaborative study published in Immunity from the Batista Lab and Liu Lab at the Ragon Institute, together…
Study elucidates key steps in the ubiquitin tagging of mutated huntingtin protein
Researchers have elucidated key steps in the ubiquitin tagging of the mutated huntingtin protein, providing hope for future…
New diagnostic framework addresses challenges of rapidly-mutating RNA viruses
The rapid evolutionary dynamics of RNA viruses, driven by high mutation rates and the consequent formation of complex…