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Browsing Tag

Oxidative Stress

31 posts
SScience
Amino acid metabolism shapes the tumor immune microenvironment and therapy response
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New nanomaterial kills cancer cells via oxidative stress

  • January 28, 2026
Scientists at Oregon State University have developed a new nanomaterial that triggers a pair of chemical reactions inside…
HHealth
Sperm cells with stethoscope on blue background. Male sexual health.
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Sperm RNA aging shift that may explain paternal age effects

  • January 22, 2026
A newly revealed “aging cliff” in sperm RNA marks a conserved molecular transition from youth to later life,…
HHealth
Study: Recreational physical activity and biomarkers of breast cancer risk in a cohort of adolescent girls. Image Credit: Svet foto / Shutterstock
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Teen girls who play organized sports show lower breast cancer risk biomarkers

  • January 20, 2026
A study of Black and Hispanic adolescent girls shows that even modest participation in organized sports is associated…
WWildlife
Yahoo news home
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Experts issue warning after observing concerning change in lizard behavior: ‘A substantial threat’

  • January 18, 2026
Winter has long served as a season of stillness, a biological pause, for hibernating animals. When that pause…
SScience
Common painkillers ibuprofen and paracetamol found to fuel antibiotic resistance
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Sub-lethal water disinfection can unintentionally boost the spread of antibiotic resistance

  • January 9, 2026
The study reveals that environmental stressors do not merely kill bacteria; they can also prime surviving cells to…
SScience
Researchers discover how plants produce cancer-fighting mitraphylline
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Glycation stress drives aortic stiffening through oxidative stress and senescence

  • December 13, 2025
A new research paper was published in Volume 17, Issue 11 of Aging-US on November 14, 2025, titled “Methylglyoxal-induced glycation stress…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
SScience
Study: Acute Impact of Polyphenol-Rich vs. Carbohydrate-Rich Foods and Beverages on Exercise-Induced ROS and FRAP in Healthy Sedentary Female Adults - A Randomized Controlled Trial. Image Credit: Improvisor / Shutterstock
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How specific foods reshape oxidative stress responses during and after high-intensity training

  • December 12, 2025
A new randomized trial reveals how simple food choices before and after fasted HIIT can shift the body’s…
TTechnology
Study: Artificial intelligence model as a tool to predict prediabetes. Image Credit: CI Photos / Shutterstock
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AI model identifies prediabetes risk with high accuracy

  • December 10, 2025
By combining oxidative stress biology with advanced machine learning, researchers show how a simple blood-based antioxidant measure can…
HHealth
Letter to the Editor: Improved Human Skin Vitamin C Levels and Skin Function after Dietary Intake of Kiwifruit: A High-Vitamin-C Food. Image Credit: Meomeow / Shutterstock
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Kiwifruit intake boosts vitamin C in skin and supports dermal structure

  • December 8, 2025
By directly measuring vitamin C inside human skin, researchers show that diet can boost skin vitamin C content…
HHealth
Lactylation drives tumor progression and immune evasion in triple negative breast cancer
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Hematological and biochemical indicators show growing value in breast cancer management

  • November 27, 2025
Breast cancer remains a predominant global health challenge for women, with late-stage diagnosis being a key contributor to…
SScience
Dysfunctional mitochondria shown to initiate the onset of Parkinson's
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Dysfunctional mitochondria shown to initiate the onset of Parkinson’s

  • November 17, 2025
For decades, scientists have known that mitochondria, which produce energy inside our cells, malfunction in Parkinson’s disease. But…
Ireland
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