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Browsing Tag

Oxygen

40 posts
HHealth
New generation of CRISPR shows safer path to treating genetic diseases
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Genetic differences in surfactant proteins influence retinopathy of prematurity risk

  • December 13, 2025
A new study from the University of Oklahoma suggests that small genetic differences in two proteins – previously…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
SScience
Study: Acute Impact of Polyphenol-Rich vs. Carbohydrate-Rich Foods and Beverages on Exercise-Induced ROS and FRAP in Healthy Sedentary Female Adults - A Randomized Controlled Trial. Image Credit: Improvisor / Shutterstock
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How specific foods reshape oxidative stress responses during and after high-intensity training

  • December 12, 2025
A new randomized trial reveals how simple food choices before and after fasted HIIT can shift the body’s…
SScience
Newly discovered biological pathway explains clotting risk in people with type 2 diabetes
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Collaborative project seeks safer therapies for ischemia and reperfusion injury

  • December 11, 2025
Southwest Research Institute (SwRI) and Trinity University will improve a prodrug, a compound activated in the body, to…
SScience
Researchers identify new molecular switch involved in programmed cell death
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Innate immunity and metabolic stress drive a unique form of cell death

  • December 2, 2025
In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study…
SScience
Less education associated with faster aging and health inequality
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Study reveals ATM kinase as the key driver of replicative senescence

  • December 2, 2025
After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres-the…
SScience
Dysfunctional mitochondria shown to initiate the onset of Parkinson's
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Dysfunctional mitochondria shown to initiate the onset of Parkinson’s

  • November 17, 2025
For decades, scientists have known that mitochondria, which produce energy inside our cells, malfunction in Parkinson’s disease. But…
HHealth
Study: Supplementation of aged garlic extract attenuates age-associated memory impairment and cognitive decline: Involvement of molecular pathways in the cortex and hippocampus. Image Credit: New Africa / Shutterstock
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Preclinical study shows aged garlic extract improves memory and reduces anxiety

  • November 17, 2025
New findings show that aged garlic extract reshapes brain pathways tied to memory and emotion, revealing a promising…
TTechnology
Image Credit: FOTOGRIN/Shutterstock.com
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Redefining control in anaerobic microbiome workflows

  • November 5, 2025
In this interview, Sheela Muley, Product Manager at Molecular Devices, and Dr Sushmita Sudarshan, Application Scientist in Assay Development at Molecular Devices,…
HHealth
Living in food deserts linked to higher stroke and death risk in atrial fibrillation patients
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Oligodendrocyte progenitor cells promote blood vessel growth after stroke

  • October 30, 2025
Stroke is a leading cause of death and disability, affecting 1 in 4 people during their lifetime. Stroke…
HHealth
Advances in ultrasound improve prenatal detection of congenital heart disease
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New imaging technique can map the blood flow of an entire organ in 4D

  • October 28, 2025
For the first time, a team of Inserm researchers from the Physics for Medicine Institute (Inserm/ESPCI Paris-PSL/CNRS) has…
HHealth
Study: Dietary Strawberries Improve Serum Antioxidant Profiles in Adults with Prediabetes: A 28-Week Randomized Controlled Crossover Trial. Image Credit: Vidic Bojan / Shutterstock
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Can strawberries help prevent diabetes? New trial shows promising results in prediabetic adults

  • October 22, 2025
Researchers found that daily freeze-dried strawberry intake enhanced antioxidant biomarkers, lowered inflammation, and improved fasting glucose, suggesting a…
Ireland
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