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Browsing Tag

Preclinical

33 posts
HHealth
Study: Total and different types of olive oil consumption, gut microbiota, and cognitive function changes in older adults. Image Credit: Mehes Daniel / Shutterstock
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Olive oil type matters for cognition and gut health in older adults

  • January 27, 2026
A large cohort study suggests that not all olive oils are equal, with virgin olive oil showing favorable…
SScience
Tiny plastic particles may interfere with brain processes implicated in Parkinson’s disease
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Tiny plastic particles may interfere with brain processes implicated in Parkinson’s disease

  • January 27, 2026
From protein misfolding to gut–brain signalling, emerging evidence suggests that everyday plastic exposure may intersect with key biological…
HHealth
Genetic mutation in some East Asians linked to aldehyde storm and increased liver disease risk
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Preclinical study reveals potential new treatment for severe liver fibrosis

  • January 14, 2026
Researchers at McMaster University are leading preclinical studies into a novel drug candidate developed by Espervita Therapeutics that has the potential to prevent and reverse liver fibrosis – a dangerous, disease-induced build-up of…
HHealth
New insights reveal persistent genome structure during cell division
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Epigenetic plasticity in germinal center B cells may help explain lymphoma origins

  • December 30, 2025
Immune cells called B cells make antibodies that fight off invading bacteria, viruses and other foreign substances. During…
HHealth
Lactylation drives tumor progression and immune evasion in triple negative breast cancer
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Study reveals a therapeutic vulnerability in aggressive subtype of triple-negative breast cancer

  • December 27, 2025
Dec 26 2025 A new study published today in Science Translational Medicine by researchers at The University of…
HHealth
Simple blood test maps hidden Alzheimer’s disease changes
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Simple blood test maps hidden Alzheimer’s disease changes

  • December 21, 2025
A large community study shows that Alzheimer’s-related brain changes are far more widespread with age than symptoms alone…
HHealth
Endoplasmic reticulum controls cell movement to repair tissue gaps
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UC Irvine receives funding for clinical trial of neural stem cell therapy for Huntington’s disease

  • December 13, 2025
Leslie M. Thompson, Donald Bren Professor of psychiatry and human behavior as well as neurobiology and behavior at…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Study: Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses. Image Credit: Corona Borealis Studio / Shutterstock
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Dietary restriction boosts antitumour immunity by rewiring T cell metabolism

  • December 11, 2025
By elevating ketone-driven energy pathways inside CD8+ T cells, dietary restriction steers them away from exhaustion and toward…
HHealth
Study: Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life. Image Credit: Art_Photo  / Shutterstock
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Early RSV infection turns maternal allergy into a powerful driver of childhood asthma

  • December 9, 2025
By combining nationwide health data with elegant immunology experiments, researchers reveal how RSV infection in infancy hijacks maternal…
HHealth
Lactylation drives tumor progression and immune evasion in triple negative breast cancer
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Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

  • December 5, 2025
Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows…
HHealth
Common painkillers ibuprofen and paracetamol found to fuel antibiotic resistance
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Novel mRNA-based therapy may offer a new path to tackle antibiotic-resistant infections

  • November 26, 2025
Researchers at the Icahn School of Medicine at Mount Sinai and collaborators have reported early success with a…
Ireland
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