New diagnostic framework addresses challenges of rapidly-mutating RNA viruses
The rapid evolutionary dynamics of RNA viruses, driven by high mutation rates and the consequent formation of complex…
Scientists uncover new mechanism initiating gene transcription
Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular…
New findings show why the human intestine uniquely presents gluten to T cells
New evidence shows that human M cells act as fully fledged antigen-presenting cells, processing and presenting gluten peptides…
Breakthrough platform reveals the choreography of mammalian transcription
Life’s instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads…
Researchers discover new mutation hotspot in the human genome
Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of DNA…
Breast cancer cells use a molecular switch to survive stress
Cells are regularly faced with environmental stresses that may damage or destroy them. To survive, they quickly adjust…
Scientists map the genetic control system behind FOXP3 in immune cells
The immune system faces a delicate balancing act: it must be aggressive enough to fight infections and cancer,…
New insights reveal how TCF and LEF proteins control Wnt signaling and disease progression
Researchers have unveiled the intricate molecular mechanisms governing TCF/LEF-mediated transcription in the canonical Wnt pathway, identifying these proteins…
Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections
Scientists have uncovered a microglial switch that transforms these immune cells from plaque-promoting to plaque-protective, offering a new…
PTGES3 emerges as key regulator of androgen receptor in prostate cancer
A poorly characterized protein, historically thought to be a chaperone or enzyme, may actually be a key player…
Eating peanuts while pregnant may influence how a child’s genes respond to breastfeeding
Researchers found that mothers who ate both peanuts and peanut butter during pregnancy had children with distinct DNA…
iNOME-seq: in vivo simultaneous genome-wide mapping of chromatin accessibility, nucleosome positioning, DNA-binding protein sites, and DNA methylation in Arabidopsis | Genome Biology
Plant lines and growth conditions The plant lines used in this study were derived from A. thaliana wild-type…