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Browsing Tag

Transplant

16 posts
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Using placental growth factor to predict preeclampsia risk in pregnant women with sickle cell disease
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New evidence shows hematopoietic cell transplantation offers durable relief for sickle cell disease

  • December 7, 2025
Patients who underwent hematopoietic cell transplantation for sickle cell disease saw high rates of survival without disease symptoms…
HHealth
Novel monoclonal antibodies show promise in preventing severe mpox disease
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Gene variant linked to higher risk of chronic rejection after lung transplant

  • December 3, 2025
About one third of lung transplant recipients have a genetic variant that makes them more likely to develop…
HHealth
Endoplasmic reticulum controls cell movement to repair tissue gaps
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Blocking immune cell signals reduces scar tissue formation in wounds

  • November 26, 2025
Researchers at the University of Arizona uncovered a previously unknown population of circulating immune cells that play a…
HHealth
Endoplasmic reticulum controls cell movement to repair tissue gaps
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Young donor age proves critical for survival after stem cell transplantation

  • November 21, 2025
The selection of suitable donors is crucial for the long-term recovery of patients after an allogeneic hematopoietic stem…
HHealthcare
Yahoo news home
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Scientists discover why pig kidneys were being rejected by transplant patients

  • November 15, 2025
Transplanting gene-edited pig kidneys into humans has been hailed as a pioneering procedure and a way to help…
HHealth
Lubiprostone shows promise in slowing kidney disease progression
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Expanding the waitlisting criteria for kidney transplantation could improve patient outcomes

  • November 10, 2025
The current kidney transplant waitlisting criterion is based on a single measurement of kidney function (estimated glomerular filtration…
HHealth
Lubiprostone shows promise in slowing kidney disease progression
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Study shows record surge in reduced kidney function worldwide

  • November 8, 2025
Record numbers of men and women globally are now estimated to have reduced kidney function, a new study…
HHealth
Lubiprostone shows promise in slowing kidney disease progression
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Machine-preserved kidneys show better function ten years after transplant

  • November 6, 2025
A long-term follow-up study from a consortium of six European countries, coordinated by the department of Surgery of…
HHealth
New study reveals a 25-year rise in alcohol-induced mortality
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One in four U.S. hepatologists screen positive for unhealthy alcohol use

  • October 16, 2025
One in four hepatologists in the United States screened positive for unhealthy alcohol use in a survey study…
WWildlife
Emergency Butterfly Wing Transplant Is a Success Watched by Millions on Social Media
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Emergency Butterfly Wing Transplant Is a Success Watched by Millions on Social Media

  • October 10, 2025
  Sweetbriar Nature Center – via Storyful With a pioneering procedure, a nature center in New York made…
GGenetics
Newborn genomic screening may detect hundreds of additional childhood conditions
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Newborn genomic screening may detect hundreds of additional childhood conditions

  • October 9, 2025
Adding genomic sequencing to newborn blood screening would detect hundreds of additional childhood conditions, providing much earlier diagnosis…
Ireland
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